Advances in biological therapy for nucleus pulposus regeneration

Osteoarthritis and Cartilage
P PriyadarshaniL Yao

Abstract

The intervertebral disc (IVD) is composed of the external annulus fibrosus (AF) and the inner gel-like center, the nucleus pulposus (NP). The elastic NP can function to relieve stress and maintain IVD function by distributing hydraulic pressure evenly to annulus and endplate. Degeneration of the NP, which leads to increased death of NP cells, the loss of proteoglycan (PG), and aberrant gene expression, may result in an overall alteration of the biomechanics of the spinal column and cause low back pain. Recent advances in biological therapy strategies that target therapy at the regeneration of degenerated and damaged NP have been investigated in in vitro and in vivo studies and demonstrated promising outcomes. In this article, we review recent studies of biological approaches for NP regeneration. The articles regarding NP regeneration using biomaterials, stem cells, and gene vectors were identified in PubMed databases. Stem cell-mediated cell therapy demonstrates the potential to restore the function and structure of the NP. The viral or non-viral vectors encoding functional genes may generate a therapeutic effect when they are introduced into grafted cells or native cells in the NP. Biomaterial scaffolds generate an initial per...Continue Reading

References

Feb 1, 1977·Rheumatology and Rehabilitation·P AdamsH Muir
Mar 1, 1991·Spine·J P ThompsonD S Bradford
May 15, 1987·The Biochemical Journal·J L DiFabioH Hughes
Apr 17, 1985·Biochimica Et Biophysica Acta·T C ColeP Ghosh
Jul 1, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S S HarrisD Feldman
Aug 19, 2003·Biomaterials·Jeanie L Drury, David J Mooney
Jan 15, 2004·Spine·Andrew J L WalshJeffrey C Lotz
Nov 16, 2004·The Spine Journal : Official Journal of the North American Spine Society·Matthew H Walker, D Greg Anderson
Apr 19, 2006·Journal of Cellular Biochemistry·Arnold I Caplan, James E Dennis
Nov 30, 2006·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·C L Le MaitreJ A Hoyland
Jan 19, 2008·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Akihiko HiyamaDaisuke Sakai
Jan 24, 2008·Pain Practice : the Official Journal of World Institute of Pain·P Prithvi Raj
Nov 14, 2008·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Rita KandelJill P G Urban
Nov 14, 2008·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Daisuke Sakai
May 21, 2009·American Journal of Physical Medicine & Rehabilitation·Yejia ZhangD Greg Anderson
Jul 31, 2010·Spine·Thomas LiebscherNorbert Boos
Sep 15, 2010·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Kenji SeriganoJoji Mochida
Oct 26, 2010·The Spine Journal : Official Journal of the North American Spine Society·Aliza A AllonJeffrey C Lotz
Dec 3, 2010·Disease Models & Mechanisms·Lachlan J SmithDawn M Elliott
Feb 1, 2011·Biomaterials·Estelle C CollinAbhay S Pandit
Jul 9, 2011·Tissue Engineering. Part a·Sang-Hyug ParkDavid L Kaplan
Sep 17, 2011·Tissue Engineering. Part a·Sang-Hyug ParkDavid L Kaplan
Sep 29, 2011·The Orthopedic Clinics of North America·Barrett I WoodsJames D Kang
Sep 29, 2011·The Orthopedic Clinics of North America·Victor Y L LeungKenneth M C Cheung
Oct 26, 2011·The Spine Journal : Official Journal of the North American Spine Society·Steven K LeckieJames D Kang
Jan 4, 2012·Journal of Biomedical Materials Research. Part a·Baichuan WangYannan Zhang

❮ Previous
Next ❯

Citations

Jan 23, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Pei LiQiang Zhou
Apr 11, 2017·Laboratory Investigation; a Journal of Technical Methods and Pathology·Kun WangCao Yang
Sep 27, 2018·Tissue Engineering. Part a·Yasaman AlinejadSophie Lerouge
Jun 12, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xiaopeng ZhouFangcai Li
Sep 10, 2019·Bio-medical Materials and Engineering·Atsuya WatanabeAntonella Schiavinato
Sep 17, 2017·Oncotarget·Zhi-Hua OuyangGuo-Hua Lv
Aug 22, 2018·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Jui-Jung YangJaw-Lin Wang
Jul 28, 2019·International Journal of Molecular Sciences·Gauri TendulkarAndreas K Nüssler
Feb 13, 2021·BioMed Research International·Daxue ZhuXuewen Kang
Jun 26, 2021·Stem Cell Reviews and Reports·Kosar MalekpourMajid Ahmadi
Aug 31, 2021·BioMed Research International·Caiping YanYuling Li

❮ Previous
Next ❯

Related Concepts

Related Feeds

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Cell-Type-Specific Viral Vectors (ASM)

Viral vectors are used in biological research and therapy to deliver genetic material into cells. However, the efficiency of viral vectors varies depending on the cell type. Here is the latest research on cell-type-specific viral vectors.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Cell-Type-Specific Viral Vectors

Viral vectors are used in biological research and therapy to deliver genetic material into cells. However, the efficiency of viral vectors varies depending on the cell type. Here is the latest research on cell-type-specific viral vectors.

AAV-based Gene Therapy

Adeno-associated virus (AAV)-based gene therapy is a biological vector that is being researched to be used as a potential therapeutic option. This gene therapy is designed to insert fragments of DNA into targeted cells to help treat diseases, such as hemophilia a. Discover the latest research on AAV-based gene therapy here.

Biomechanics

Biomechanics examines the generation of internal forces within the body and investigates the effects and control of forces that act on or are produced on tissues. Here are the latest discoveries.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Cell-Type Specific Viral Vectors

Viral vectors are used in biological research and therapy to deliver genetic material into cells. However, the efficiency of viral vectors varies depending on the cell type. Here is the latest research on cell-type-specific viral vectors.

Related Papers

The Spine Journal : Official Journal of the North American Spine Society
Matthew H Walker, D Greg Anderson
European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
Ricardo Rodrigues-PintoJudith A Hoyland
Clinical Neurosurgery
Benjamin P B TowJeffrey C Wang
© 2021 Meta ULC. All rights reserved