Advances in biomaterials for skeletal muscle engineering and obstacles still to overcome

Materials Today. Bio
M M Smoak, A G Mikos

Abstract

Repair of injured skeletal muscle is a sophisticated process that uses immune, muscle, perivascular, and neural cells. In acute injury, the robust endogenous repair process can facilitate complete regeneration with little to no functional deficit. However, in severe injury, the damage is beyond the capacity for self-repair, often resulting in structural and functional deficits. Aside from the insufficiencies in muscle function, the aesthetic deficits can impact quality of life. Current clinical treatments are significantly limited in their capacity to structurally and functionally repair the damaged skeletal muscle. Therefore, alternative approaches are needed. Biomaterial therapies for skeletal muscle engineering have leveraged natural materials with sophisticated scaffold fabrication techniques to guide cell infiltration, alignment, and differentiation. Advances in biomaterials paired with a standardized and rigorous assessment of resulting tissue formation have greatly advanced the field of skeletal muscle engineering in the last several years. Herein, we discuss the current trends in biomaterials-based therapies for skeletal muscle regeneration and present the obstacles still to be overcome before clinical translation is po...Continue Reading

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Citations

Sep 13, 2020·Nanomaterials·Sara PolitiLaura Teodori
Nov 5, 2020·International Journal of Molecular Sciences·Sissel B RønningMona E Pedersen
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Aug 5, 2021·Journal of Tissue Engineering·Huajian ShanXiaozhong Zhou
Nov 9, 2021·Nanomedicine·Franco TacchiClaudio Cabello-Verrugio

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Methods Mentioned

BETA
biopsies
PCL
ELISA
enzyme-linked immunosorbent assay
PCR
ELISAs

Software Mentioned

Photoshop
ImageJ

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