Advances in circular RNAs and their roles in breast Cancer

Journal of Experimental & Clinical Cancer Research : CR
Xuehui Wang, Lin Fang

Abstract

Circular RNAs (circRNAs) are a type of noncoding RNAs with a closed loop structure. With the development of high-throughput sequencing, massive circRNAs have been discovered in tumorous tissues. Emerging evidence suggests that the biological functions of circRNAs including serving as ceRNAs or miRNA sponges, interacting with proteins, regulating gene transcription and translation, suggesting that circRNAs will be novel biomarkers and targets for the diagnosis and prognosis of diseases. Breast cancer is the most frequently occurring cancer and the leading cause of cancer-related death among women worldwide. It is vital to understand the molecular pathways involved in the pathogenesis of proliferation and progression. In this review, we summarize the current knowledge on human circRNAs and their potential clinical implications on breast cancer.

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Citations

Jan 16, 2020·Diagnostics·Maria Yu KonoshenkoPavel P Laktionov
Jan 10, 2020·Epigenomics·Manon DuforestelPierre-François Cartron
Jul 22, 2020·Journal of Cellular and Molecular Medicine·Chen WuAihua Yao
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Jan 14, 2021·Journal of Experimental & Clinical Cancer Research : CR·Xuehui WangLin Fang
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Feb 1, 2022·Journal of Clinical Laboratory Analysis·Zahra FirooziYaser Mansoori

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Methods Mentioned

BETA
electron microscopy
nuclear translocation
Circ-Seq
RNA-seq
PCR
immunoprecipitation
pull down

Software Mentioned

Cirbase
Circ2Traits
circ
CircRNADb
CircInteractome
CIRCexplorer
finder
Circnet
circRNA
CIRI

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