Advances in Closed-Loop Insulin Delivery Systems in Patients with Type 1 Diabetes

Current Diabetes Reports
Vikash DadlaniYogish C Kudva

Abstract

To provide a current review of closed-loop insulin delivery or artificial pancreas (AP) as therapy for people with type 1 diabetes mellitus (T1D) RECENT FINDINGS: The Medtronic Minimed 670G AP system has been in use in clinical practice since March 2017. Currently, Medtronic is conducting a large randomized clinical trial to evaluate its efficacy further in T1D. Simultaneously, the NIH has funded four research consortia to accelerate progress to approval of other AP and decision support systems. Several research groups are currently developing next-generation AP systems, with a number of companies moving toward releasing closed-loop systems in the future. AP systems are also being tested in select populations such as hypoglycemia-unaware T1D and pregnant T1D. AP research is rapidly advancing. The clinical range of AP will be expanded in the next decade.

Associated Clinical Trials

Apr 9, 2021·Caroline Zuijdwijk

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Dec 24, 2018·Diabetic Medicine : a Journal of the British Diabetic Association·K T D YeungS Purkayastha
Feb 21, 2019·Diabetes Technology & Therapeutics·Revital NimriEyal Dassau
Aug 27, 2019·Diabetes Technology & Therapeutics·Stephanie S CrossenNicole S Glaser
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Aug 24, 2019·Diabetes & Metabolism Journal·Giacomo CapponAndrea Facchinetti
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Aug 28, 2020·Diabetes Technology & Therapeutics·Jordan E PinskerSteph Habif
May 25, 2021·Bioengineering & Translational Medicine·Kelilah L WolkowiczEyal Dassau
Feb 5, 2022·Journal of Diabetes Science and Technology·Eleonora M AielloEyal Dassau

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