Dec 14, 2018

Advances in developing novel therapeutic strategies for Alzheimer's disease

Molecular Neurodegeneration
Jiqing CaoDongming Cai

Abstract

Alzheimer's Disease (AD), the most prevalent neurodegenerative disease of aging, affects one in eight older Americans. Nearly all drug treatments tested for AD today have failed to show any efficacy. There is a great need for therapies to prevent and/or slow the progression of AD. The major challenge in AD drug development is lack of clarity about the mechanisms underlying AD pathogenesis and pathophysiology. Several studies support the notion that AD is a multifactorial disease. While there is abundant evidence that amyloid plays a role in AD pathogenesis, other mechanisms have been implicated in AD such as tangle formation and spread, dysregulated protein degradation pathways, neuroinflammation, and loss of support by neurotrophic factors. Therefore, current paradigms of AD drug design have been shifted from single target approach (primarily amyloid-centric) to developing drugs targeted at multiple disease aspects, and from treating AD at later stages of disease progression to focusing on preventive strategies at early stages of disease development. Here, we summarize current strategies and new trends of AD drug development, including pre-clinical and clinical trials that target different aspects of disease (mechanism-based v...Continue Reading

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Mentioned in this Paper

Drug Development
Bone Diseases, Developmental
Study
Familial Alzheimer Disease (FAD)
American
Pathogenesis
Nerve Degeneration
Alzheimer's Disease
Pharmacologic Substance
Prophylactic Treatment

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