Advances in drug delivery to the posterior segment

Current Opinion in Ophthalmology
William PearceSteven Yeh

Abstract

Emerging developments and research for drug delivery to the posterior segment offer a promising future for the treatment of vitreoretinal disease. As new technologies enter the market, clinicians should be aware of new indications and ongoing clinical trials. This review summarizes the advantages and shortcomings of the most commonly used drug delivery methods, including vitreous dynamics, physician sustainability and patient preferences. Currently available, intravitreal, corticosteroid-release devices offer surgical and in-office management of retinal vascular disease and posterior uveitis. The suprachoroidal space offers a new anatomic location for the delivery of lower dose medications directly to the target tissue. Implantable drug reservoirs would potentially allow for less frequent intravitreal injections reducing treatment burdens and associated risks. Newer innovations in encapsulated cell technology offer promising results in early clinical trials. Although pars plana intravitreal injection remains the mainstay of therapy for many vitreoretinal diseases, targeted delivery and implantable eluting devices are rapidly demonstrating safety and efficacy. These therapeutic modalities offer promising options for the vitreore...Continue Reading

References

Sep 23, 2006·American Journal of Ophthalmology·Timothy W OlsenJ Douglas Cameron
Sep 14, 2007·Ophthalmic Research·Stephanie H KimMichael R Robinson
Sep 10, 2008·Archives of Ophthalmology·David G CallananTimothy L Comstock
Apr 28, 2009·Biomedical Microdevices·Ronalee LoEllis Meng
Mar 10, 2010·Archives of Ophthalmology·Robert J CampbellSudeep S Gill
Apr 9, 2010·Current Eye Research·Saloomeh SaatiMark S Humayun
Nov 1, 1945·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·A FEIGENBAUM, W KORNBLUTH
Jan 12, 2011·Archives of Ophthalmology·Careen LowderUNKNOWN Ozurdex HURON Study Group
Feb 25, 2011·The New England Journal of Medicine·Deborah A Martin, Sanjaya Senanayake
Mar 30, 2011·Proceedings of the National Academy of Sciences of the United States of America·Kang ZhangGeorge A Williams
Mar 31, 2011·Investigative Ophthalmology & Visual Science·Timothy W OlsenJ Douglas Cameron
Jun 7, 2012·Investigative Ophthalmology & Visual Science·Samirkumar R PatelMark R Prausnitz
Oct 23, 2012·Ophthalmology·Jeffrey S HeierUNKNOWN VIEW 1 and VIEW 2 Study Groups
May 15, 2013·American Journal of Ophthalmology·David G BirchUNKNOWN Ciliary Neurotrophic Factor Retinitis Pigmentosa Study Groups
Jun 19, 2013·Survey of Ophthalmology·Weerawat KiddeeYvonne M Buys
Apr 5, 2014·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Monica L BrattonDavid R Weakley

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Citations

Oct 21, 2015·Progress in Retinal and Eye Research·Daniela FerraraJay S Duker
Jan 27, 2016·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Pooja BansalPradeep Venkatesh
Jun 27, 2015·Progress in Retinal and Eye Research·Viviana GuadagniEnrica Strettoi
Oct 18, 2016·Current Eye Research·Corinne G WongTimothy You
Apr 21, 2017·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Rohit BishtIlva D Rupenthal
Sep 3, 2017·British Journal of Pharmacology·Sahar AwwadAlastair Lockwood
Jan 25, 2019·Current Pharmaceutical Design·Elad Moisseiev, Anat Loewenstein
Dec 28, 2019·Pharmaceutics·Natallia DubashynskayaYury A Skorik
Jul 4, 2020·Expert Opinion on Drug Delivery·Shuying WangW John Kao
Aug 27, 2019·F1000Research·Riccardo SacconiFrancesco Bandello
Jan 5, 2021·Expert Opinion on Drug Delivery·Shelley E HancockThomas A Ciulla
Mar 6, 2021·International Medical Case Reports Journal·João Heitor MarquesJoão Melo Beirão
Jul 15, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Mark KrauthammerElad Moisseiev
Aug 13, 2021·Drug Delivery and Translational Research·Muhammad Faris AdriantoRaghu Raj Singh Thakur

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Clinical Trials Mentioned

NCT01186432
NCT02125266
NCT02303184
NCT01789320

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