Advances in drug discovery for human beta cell regeneration

Diabetologia
Esra KarakoseAndrew F Stewart

Abstract

The numbers of insulin-secreting pancreatic beta cells are reduced in people with type 1 and type 2 diabetes. Driving beta cell regeneration in the pancreases of people with diabetes would be an attractive approach to reversing diabetes. While adult human beta cells have long been believed to be terminally differentiated and, therefore, irreversibly quiescent, it has become clear over recent years that this is not true. More specifically, both candidate and unbiased high-throughput screen approaches have revealed several classes of molecules that are clearly able to induce human beta cell proliferation. Here, we review recent approaches and accomplishments in human beta cell regenerative drug discovery. We also list the challenges that this rapidly moving field must confront to translate beta cell regenerative therapy from the laboratory to the clinic.

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Jul 23, 2020·Nature Metabolism·Dario F De Jesus, Rohit N Kulkarni
Nov 11, 2020·Scientific Reports·Yun-Fang JiaChong Hyun Shin
Jan 4, 2021·Molecular Biology Reports·Tapan BehlSimona Bungau
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Mar 9, 2021·Journal of Medicinal Chemistry·Kunal KumarRobert J DeVita
Jul 30, 2021·Biochemical Pharmacology·Indira PurushothamanPatricia J McLaughlin

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