Advances in experimental and mechanistic computational models to understand pulmonary exposure to inhaled drugs

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Per BäckmanAmrit Paudel

Abstract

Prediction of local exposure following inhalation of a locally acting pulmonary drug is central to the successful development of novel inhaled medicines, as well as generic equivalents. This work provides a comprehensive review of the state of the art with respect to multiscale computer models designed to provide a mechanistic prediction of local and systemic drug exposure following inhalation. The availability and quality of underpinning in vivo and in vitro data informing the computer based models is also considered. Mechanistic modelling of local exposure has the potential to speed up and improve the chances of successful inhaled API and product development. Although there are examples in the literature where this type of modelling has been used to understand and explain local and systemic exposure, there are two main barriers to more widespread use. There is a lack of generally recognised commercially available computational models that incorporate mechanistic modelling of regional lung particle deposition and drug disposition processes to simulate free tissue drug concentration. There is also a need for physiologically relevant, good quality experimental data to inform such modelling. For example, there are no standardized...Continue Reading

Citations

Mar 29, 2018·Drug Delivery·Erica BäckströmMarkus Fridén
Aug 8, 2018·CPT: Pharmacometrics & Systems Pharmacology·Elin Boger, Oskar Wigström
Nov 23, 2018·Expert Opinion on Drug Delivery·P Worth LongestMichael Hindle
May 3, 2019·CPT: Pharmacometrics & Systems Pharmacology·Ross L WalengaLiang Zhao
Mar 19, 2019·Journal of Pharmacokinetics and Pharmacodynamics·Kosmas Kosmidis, George Dassios
Nov 21, 2018·Clinical Pharmacology and Therapeutics·Rajesh Krishna, Filippos Kesisoglou
Nov 6, 2018·Expert Opinion on Drug Delivery·Andrew R MartinWarren H Finlay
Jul 19, 2018·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·Jens Markus BorghardtAshish Sharma
Dec 5, 2020·International Journal of Molecular Sciences·Mohammed Ali SeloJohanna J Salomon
Jan 9, 2021·Expert Opinion on Drug Delivery·Maria Gabriella MateraMario Cazzola
Mar 27, 2021·Computers in Biology and Medicine·Jianan ZhaoN Sarah Arden
Jul 19, 2021·International Journal of Pharmaceutics·Snezana RadivojevEleonore Fröhlich
May 29, 2019·Molecular Pharmaceutics·Johanna ErikssonHans Lennernäs
Aug 31, 2021·Advanced Drug Delivery Reviews·Michael Yee Tak ChowPhilip Chi Lip Kwok
Sep 22, 2021·Drug Discovery Today·Elisa PasquaChris Hurley

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