Advances in Fluorescent Single-Chain Nanoparticles

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Julen De-La-CuestaJosé A Pomposo

Abstract

Fluorophore molecules can be monitored by fluorescence spectroscopy and microscopy, which are highly useful and widely used techniques in cell biology, biochemistry, and medicine (e.g., biomarker analysis, immunoassays, cancer diagnosis). Several fluorescent micro- and nanoparticle systems based on block copolymer micelles and cross-linked polymer networks, quantum dots, π-conjugated polymers, and dendrimers have been evaluated as optical imaging systems. In this review, we highlight recent advances in the construction of fluorescent single-chain nanoparticles (SCNPs), which are valuable artificial soft nano-objects with a small tunable size (as small as 3 nm). In particular, the main methods currently available to endow SCNPs with fluorescent properties are discussed in detail, showing illustrative examples.

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Citations

Jul 31, 2019·Methods and Applications in Fluorescence·Hsin-Yun TsaiW Russ Algar
Oct 1, 2020·Soft Matter·Beatriz Robles-HernándezÁngel Alegría
Jun 15, 2018·Chemical Science·Tobias S FischerChristopher Barner-Kowollik
Sep 3, 2020·Nanomaterials·Sarkar Siddique, James C L Chow
Jul 21, 2021·Chemical Reviews·W Russ AlgarHyungki Kim
Aug 29, 2019·ACS Omega·José A PomposoJuan Colmenero
Dec 7, 2018·Chemical Reviews·Teresa L MakoMindy Levine

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Methods Mentioned

BETA
size
dynamic
atomic
transmission electron microscopy
fluorescence
AFM
fluorescence microscopy

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