Advances in Fmoc solid-phase peptide synthesis

Journal of Peptide Science : an Official Publication of the European Peptide Society
Raymond BehrendtJohn Offer

Abstract

Today, Fmoc SPPS is the method of choice for peptide synthesis. Very-high-quality Fmoc building blocks are available at low cost because of the economies of scale arising from current multiton production of therapeutic peptides by Fmoc SPPS. Many modified derivatives are commercially available as Fmoc building blocks, making synthetic access to a broad range of peptide derivatives straightforward. The number of synthetic peptides entering clinical trials has grown continuously over the last decade, and recent advances in the Fmoc SPPS technology are a response to the growing demand from medicinal chemistry and pharmacology. Improvements are being continually reported for peptide quality, synthesis time and novel synthetic targets. Topical peptide research has contributed to a continuous improvement and expansion of Fmoc SPPS applications.

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Citations

Apr 27, 2016·Journal of Peptide Science : an Official Publication of the European Peptide Society·Martin Engelhard
Jun 28, 2016·Journal of the American Chemical Society·Alejandro M FracaroliOmar M Yaghi
Aug 16, 2016·Amino Acids·Jeannette GonzalezJason P Schwans
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Apr 19, 2017·Bioorganic & Medicinal Chemistry Letters·Nixon Corpuz, Jason P Schwans
Sep 23, 2016·Angewandte Chemie·Richard RazJohn Offer
Jan 26, 2017·Journal of Peptide Science : an Official Publication of the European Peptide Society·Cédric RentierYoshio Hayashi
Feb 1, 2017·Journal of Peptide Science : an Official Publication of the European Peptide Society·Andrea CaporaleMenotti Ruvo
Jul 7, 2017·Physical Chemistry Chemical Physics : PCCP·Lola SbiccaNadia Patino
Feb 16, 2018·Journal of Peptide Science : an Official Publication of the European Peptide Society·Yan CuiYoshio Hayashi
Nov 15, 2016·Organic & Biomolecular Chemistry·Steve JobinEric Biron
Aug 10, 2018·Organic & Biomolecular Chemistry·Anna KovalováMilan Vrabel
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Oct 6, 2018·Journal of Peptide Science : an Official Publication of the European Peptide Society·Juan M Gurevich MessinaSilvia A Camperi
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Mar 13, 2019·Journal of Peptide Science : an Official Publication of the European Peptide Society·Federica TonoloMaria Pia Rigobello
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Jul 23, 2019·Organic & Biomolecular Chemistry·Babita BishtNandita Madhavan
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Oct 23, 2019·Biological Chemistry·Shiyu ChenMatthew Bogyo
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Aug 5, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Nicholas G FischerConrado Aparicio

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Methods Mentioned

BETA
silylation
acylation
glycosylation
dissection

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