Advances in hemophilia: experimental aspects and therapy

Hematology/oncology Clinics of North America
Nidra I Rodriguez, W Keith Hoots

Abstract

This article describes recent clinical and research advances in hemophilia therapy. Different prophylactic regimens for the management of severe hemophilia are described along with the use of adjuvant treatment options to achieve hemostasis. The safety and efficacy of radionuclide synovectomy with phosphorus 32-sulfur colloid to treat existing joint arthropathy also are described. The development of inhibitors to factor VIII or IX remains a challenge for hemophilia care and recent approaches to achieve immune tolerance induction are discussed. Finally, recent advances in hemophilia are mentioned, including the role of iron, inflammation, and angiogenesis in the pathogenesis of hemophilic arthropathy.

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Citations

Sep 26, 2012·Haemophilia : the Official Journal of the World Federation of Hemophilia·M D TarantinoM P Luo
Apr 5, 2013·Therapeutic Advances in Hematology·Karin Knobe, Erik Berntorp

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