Advances in hepatitis B and C

Current Opinion in Infectious Diseases
Emma C Thomson, Janice Main

Abstract

Hepatitis B and C infections are prevalent around the world and a major health burden due to the associated complications of hepatic fibrosis, cirrhosis and hepatocellular carcinoma which occur in the context of chronic infection. Significant advances are being made in assessing and treating infected patients and recent studies are now targeting patients who have failed to respond to previous treatments or who have associated co-morbidities. The purpose of this article to review the recent literature on the subject of hepatitis B and C infections with particular focus on new treatment options, new approaches in patients who have previously failed therapy and in those who have co-morbidity. A large number of studies have been carried out investigating the roles of varying doses, targeting treatment in particular groups and new treatment options in patients infected with hepatitis B and C. Several key findings such as the value of prolonging treatment in patients with genotype 1 hepatitis C infection, the use of pegylated interferon in chronic hepatitis B infection and the emergence of new treatments such as adefovir for resistant hepatitis B infection, as well as treatment of patients co-infected with hepatitis C and human immun...Continue Reading

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Citations

Jan 14, 2005·Current Opinion in Infectious Diseases·Mark Atkins, Marianne Nolan
Dec 24, 2005·The Journal of Antimicrobial Chemotherapy·Cosme Alvarado-EsquivelErwin Sablon
Oct 31, 2006·World Journal of Gastroenterology : WJG·Cosme Alvarado-EsquivelSergio Aguilar-Benavides

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