Advances in human primordial follicle activation and premature ovarian insufficiency

Reproduction : the Official Journal of the Society for the Study of Fertility
Emmalee A FordJessie M Sutherland

Abstract

In women, the non-growing population of follicles that comprise the ovarian reserve is determined at birth and serves as the reservoir for future fertility. This reserve of dormant, primordial follicles and the mechanisms controlling their selective activation which constitute the committing step into folliculogenesis are essential for determining fertility outcomes in women. Much of the available data on the mechanisms responsible for primordial follicle activation focuses on a selection of key molecular pathways, studied primarily in animal models, with findings often not synonymous in humans. The excessive induction of primordial follicle activation may cause the development of premature ovarian insufficiency (POI), a condition characterised by menopause before age 40 years. POI affects 1-2% of all women and is accompanied by additional health risks. Therefore, it is critical to further our understanding of primordial follicle activation in order to diagnose, treat and prevent premature infertility. Research in primordial follicle activation has focused on connecting new molecules to already established key signalling pathways, such as phosphatidylinositol 3-Kinase (PI3K) and mammalian target of rapamycin (mTOR). Additionall...Continue Reading

Citations

Nov 2, 2019·Animals : an Open Access Journal From MDPI·Meng CaoDe Wu
Jul 29, 2020·Molecular Reproduction and Development·Kathryn J Grive
Sep 9, 2020·Climacteric : the Journal of the International Menopause Society·N PanayW Wolfman
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Oct 27, 2020·Frontiers in Cell and Developmental Biology·Yao ChenDonghui Huang
Jul 21, 2020·Trends in Endocrinology and Metabolism : TEM·Reinaldo Barreto OriáJosé Ricardo Figueiredo
Apr 24, 2021·Genes & Development·Emily R FrostJessie M Sutherland
Jun 3, 2021·International Journal of Molecular Sciences·Yingjun ChenChangjiu He
May 27, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Lingdi WangHongyan Yang
Jul 7, 2021·Journal of Biomedical Materials Research. Part a·Mahdieh SarabadaniRouhollah Fathi
Dec 1, 2021·Histochemistry and Cell Biology·Ren TanimotoYayoi Obata

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