Advances in immunosuppression for renal transplantation.

Nature Reviews. Nephrology
Antoine DurrbachBernard Charpentier

Abstract

The development of immunosuppressants with minimal adverse and nephrotoxic effects is important to improve outcomes, such as acute and chronic antibody-mediated rejection, after organ transplantation. In addition, the application of expanded criteria for donors and transplantation in immunized patients necessitates the development of new therapies. Drug development over the past 10 years has generally been disappointing, but several new promising compounds have been or are being developed to prevent acute and chronic transplant rejection. In this Review, we report on several compounds that have been developed to remove allogenic T cells and/or to inhibit T-cell activation. We also discuss compounds that interfere with antibody-mediated rejection.

References

Nov 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·L A TurkaD Gordon
Aug 1, 1991·European Journal of Immunology·S DanielianS Fischer
Nov 3, 1995·Science·T NosakaJ N Ihle
Jul 1, 1993·The Journal of Experimental Medicine·G T MillerB P Wallner
Feb 24, 1995·Cell·D Thanos, T Maniatis
Jun 27, 1994·Transplantation·T C PearsonC P Larsen
Jan 1, 1996·Annual Review of Immunology·A S Baldwin
Apr 10, 1997·The New England Journal of Medicine·P J Barnes, M Karin
Aug 5, 1997·Proceedings of the National Academy of Sciences of the United States of America·A D KirkS J Knechtle
Aug 1, 1997·Current Opinion in Immunology·D C Thomis, L J Berg
Apr 7, 1998·Immunity·M K SlifkaR Ahmed
May 23, 1998·Annual Review of Immunology·S GhoshE B Kopp
May 23, 1998·Annual Review of Immunology·W J Leonard, J J O'Shea
Jun 25, 1998·Current Opinion in Immunology·K D LiuM A Goldsmith
Oct 2, 1998·Advances in Immunology·B H Nelson, D M Willerford
Mar 20, 1999·Transplantation Proceedings·A D HibberdA P Disney
Apr 13, 1999·Lancet·M D DentonM H Sayegh
May 14, 1999·Current Opinion in Immunology·M G McHeyzer-Williams, R Ahmed
Mar 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·F BehbodR A Kirken
Mar 13, 2001·Annual Review of Immunology·S K BromleyM L Dustin
Mar 27, 2001·Transplantation Proceedings·C DumontA Senik
Jul 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·A LongY Volkov

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Citations

Oct 19, 2010·Journal of Transplantation·Rajeev RaghavanAbdul Abdellatif
Nov 17, 2010·Molecular Medicine·Nan LuXiong Zou
Dec 12, 2012·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Ali GhorbaniAzade Taheri
Aug 21, 2013·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Chad A WittRamsey R Hachem
Dec 8, 2015·The Journal of Arthroplasty·Mitchell R KlementThorsten M Seyler
Aug 21, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·F Waldron-LynchK C Herold
Sep 12, 2015·The Korean Journal of Internal Medicine·Ji Hyun YuChul Woo Yang
Mar 12, 2015·Progress in Transplantation : Official Publication, North American Transplant Coordinators Organization ... [et Al.]·Badri ShresthaAndrew Raftery
Feb 27, 2016·European Journal of Clinical Pharmacology·Johann Castañeda-SanabriaFlorence Tubach
Mar 7, 2014·Progress in Transplantation : Official Publication, North American Transplant Coordinators Organization ... [et Al.]·Michal WszolaAndrzej Chmura
Nov 9, 2012·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Ruth-Ann Lee, Steven Gabardi
Jul 12, 2013·The Journal of Veterinary Medical Science·Kyung-Mee ParkHeung-Myong Woo
Oct 9, 2013·Current Opinion in Nephrology and Hypertension·Kassem SafaAnil Chandraker
Nov 1, 2017·British Medical Bulletin·S DholakiaP J Friend
May 28, 2020·Jornal brasileiro de nefrologia : ʹorgão oficial de Sociedades Brasileira e Latino-Americana de Nefrologia·José A Moura-NetoNordeval Cavalcante Araújo
Jun 15, 2011·Current Opinion in Organ Transplantation·Keri E LunsfordTodd V Brennan
Jun 26, 2020·Frontiers in Cell and Developmental Biology·Yutian LeiHans-Joachim Anders
Apr 4, 2021·International Journal of Molecular Sciences·Jakub RosikAndrzej Pawlik

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