Advances in immunotherapy for colorectal cancer: a review

Therapeutic Advances in Gastroenterology
Gol Golshani, Yue Zhang

Abstract

Immunotherapy is a new and exciting modality of cancer treatments. Its role in gastrointestinal malignancies has been promising, especially in advanced disease. Although various therapies are available for treatment of advanced colorectal cancer, survival rates for these patients remain very poor. The application of immunotherapy in colorectal cancer has shown remarkable results for a subset of patients with mismatch-repair-deficient mutations or microsatellite instability in their tumors. This literature review evaluates the current role of immunotherapy in advanced colorectal cancer, potential challenges clinicians face with immunotherapy-based regimens, and the possible future approach of combined modality immunotherapy.

References

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Citations

Jan 15, 2021·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Dushyant Singh DahiyaManidhar Lekkala
Jan 15, 2021·International Journal of Molecular Sciences·Hantae JoMi-Gi Lee
Nov 24, 2020·OncoTargets and Therapy·Xianzhe YuJianguo Li
Jan 21, 2021·Biomedicines·Kyusang HwangSukmook Lee
Mar 16, 2021·Cancer Treatment Reviews·Elisabetta PuligaSilvia Giordano
Apr 14, 2021·Seminars in Cancer Biology·Pietro AndreiAlberto Bardelli
May 6, 2021·Biomaterials Science·Maria José SilveiraBruno Sarmento
Jun 10, 2021·Advances in Therapy·Caterina ArruPanagiotis Paliogiannis
Jun 3, 2021·Cancers·Mariken E StegmannDaan Brandenbarg
Jun 7, 2021·Journal of Experimental & Clinical Cancer Research : CR·Erika DurinikovaSabrina Arena
Jun 19, 2021·International Journal of Surgical Pathology·Adrian C Bateman
Jun 22, 2021·Frontiers in Oncology·Isabella GuardamagnaGiorgio Baiocco
Aug 28, 2021·Biomedicines·Daniel-Clement Osei-BordomNiki Christou
Oct 6, 2021·Pharmacology Research & Perspectives·María de la Paz SarasolaVanina A Medina
Nov 16, 2021·Frontiers in Bioengineering and Biotechnology·Nan WangZhiyong Ding

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Methods Mentioned

BETA
PCR

Clinical Trials Mentioned

NCT02576509
NCT03642067
NCT03647839
NCT03832621
NCT03007407
NCT03396926
NCT03631407
NCT03104439
NCT03608046
NCT03800602

Software Mentioned

IMPALA
MODUL

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