PMID: 2490110Jan 1, 1989Paper

Advances in liquid chromatography and related methodologies for therapeutic drug monitoring

Journal of Pharmaceutical and Biomedical Analysis
S H Wong

Abstract

In this article the merits of current liquid chromatography (LC) columns and techniques are reviewed, to include the following topics: (1) a brief introduction to rational therapeutic drug monitoring (TDM) to justify drug measurements; (2) selected recent survey results from the College of American Pathologists (CAP) to establish the current utilization pattern of LC for TDM in the USA; (3) LC analyses of major classes of drugs--antiarrhythmics, antidepressants, antiepileptics, antimicrobials, cyclosporine, and others--with emphasis on analysis of these drugs in human serum or plasma, by focusing on the less usual, reversed-phase functional groups such as CN and phenyl, and by the use of "mini" columns, silica and polymeric columns, the emphasis being reduced on the well-established C-18 columns; (4) high-speed LC; (5) various approaches of direct sample analysis--solvent extraction, automated sample processing, column switching, micro-injections, micellar chromatography, electrochemical detection with photolytic derivation, and the internal surface reversed-phase column of Pinkerton; (6) microbore LC drug analysis; (7) clinical chiral separation; and (8) overall conclusions.

References

May 1, 1978·Archives of General Psychiatry·D S RobinsonD Bartlett
Oct 24, 1986·Journal of Chromatography·S E Cook, T C Pinkerton
Jan 1, 1987·Therapeutic Drug Monitoring·J J MacKichan, B J Shields
Sep 1, 1987·Therapeutic Drug Monitoring·M FurlanutG Colombo
Nov 1, 1982·Clinical Endocrinology·H N CohenG G Klee
Jan 1, 1986·Journal of Pharmaceutical and Biomedical Analysis·N DaoudK G Wahlund
Jan 1, 1986·Journal of Pharmaceutical and Biomedical Analysis·R D McDowallG S Murkitt
Jan 1, 1985·Journal of Pharmaceutical and Biomedical Analysis·L J LoveM Arunyanart

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Citations

Dec 6, 2003·Journal of Pharmaceutical and Biomedical Analysis·C Pistos, James T Stewart
May 30, 2006·Clinical Biochemistry·Loralie J Langman, Bhushan M Kapur
Jan 1, 1990·Journal of Pharmaceutical and Biomedical Analysis·S H Wong

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