Advances in Liver Regeneration: Revisiting Hepatic Stem/Progenitor Cells and Their Origin

Stem Cells International
Ali-Reza SadriSaeid Amini-Nik

Abstract

The liver has evolved to become a highly plastic organ with extraordinary regenerative capabilities. What drives liver regeneration is still being debated. Adult liver stem/progenitor cells have been characterized and used to produce functional hepatocytes and biliary cells in vitro. However, in vivo, numerous studies have questioned whether hepatic progenitor cells have a significant role in liver regeneration. Mature hepatocytes have recently been shown to be more plastic than previously believed and give rise to new hepatocytes after acute and chronic injury. In this review, we discuss current knowledge in the field of liver regeneration and the importance of the serotonin pathway as a clinical target for patients with liver dysfunction.

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Citations

Mar 8, 2017·Scientific Reports·Andrea RemuzziGiuseppe Remuzzi
Mar 30, 2018·International Journal of Molecular Sciences·Alia SadiqSaeid Amini-Nik
Mar 27, 2019·Cell Biology International·Ying XuJu Liu
Sep 21, 2016·Artificial Cells, Nanomedicine, and Biotechnology·Yousef AminiMahdi Fasihi-Ramandi
Aug 28, 2020·International Journal of Molecular Sciences·Lucie ČtveráčkováIva Sovadinová
Nov 11, 2020·Neurobiology of Disease·Stefan H Stricker, Magdalena Götz
Feb 27, 2021·Biomaterials Research·Maqsood Ali, Samantha L Payne
Mar 20, 2021·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Yueming XueShufang Wang

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