Apr 7, 2016

Advances in Magnetic Resonance Imaging Contrast Agents for Biomarker Detection

Annual Review of Analytical Chemistry
Sanhita Sinharay, Mark D Pagel

Abstract

Recent advances in magnetic resonance imaging (MRI) contrast agents have provided new capabilities for biomarker detection through molecular imaging. MRI contrast agents based on the T2 exchange mechanism have more recently expanded the armamentarium of agents for molecular imaging. Compared with T1 and T2* agents, T2 exchange agents have a slower chemical exchange rate, which improves the ability to design these MRI contrast agents with greater specificity for detecting the intended biomarker. MRI contrast agents that are detected through chemical exchange saturation transfer (CEST) have even slower chemical exchange rates. Another emerging class of MRI contrast agents uses hyperpolarized (13)C to detect the agent with outstanding sensitivity. These hyperpolarized (13)C agents can be used to track metabolism and monitor characteristics of the tissue microenvironment. Together, these various MRI contrast agents provide excellent opportunities to develop molecular imaging for biomarker detection.

  • References91
  • Citations14

References

  • References91
  • Citations14

Citations

Mentioned in this Paper

Biological Markers
Metabolic Process, Cellular
ErbB-2 Receptor
Molecular Imaging
Tumor Cells, Uncertain Whether Benign or Malignant
Biochemical Pathway
Creatinine
Alb
Hydrogen Ion Concentration Measurement
Amines

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