Advances in management of bone disease in breast cancer

Bone
L Walkington, R E Coleman

Abstract

Breast cancer is the commonest malignancy diagnosed in women. Although there have been huge advances in treatment in recent years leading to excellent outlooks for many women, a significant number of patients are developing bone complications. This is often due to metastatic bone disease, which occurs in approximately 70% of women with advanced breast cancer. Additionally, accelerated bone loss and associated complications such as fractures may be a consequence of adjuvant treatment. Whatever the cause, cancer-induced bone disease can have potentially devastating clinical consequences for the patient, and results in a considerable economic burden to the health care provider. This review addresses the causes and sequelae of bone disease in both early and advanced breast cancer. The evidence for preserving bone health, both with traditional treatments such as bisphosphonates and newer agents, including antibody therapy is reviewed, with recommendations for current practice. Finally, we discuss the emerging potential role of bone-targeting therapies in preventing the development of metastatic disease.

References

Aug 3, 2002·Nature Reviews. Cancer·Gregory R Mundy
Sep 5, 2003·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J-J BodyUNKNOWN MF 4265 Study Group
Sep 30, 2004·International Journal of Cancer. Journal International Du Cancer·Helen L Neville-WebbeIngunn Holen
Apr 26, 2005·Cancer Treatment Reviews·James LesterRobert Coleman
Oct 26, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Robert E Coleman
Aug 1, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sundeep KhoslaUNKNOWN American Society for Bone and Mineral Research
Dec 17, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stephanie L HinesEdith A Perez
Sep 5, 2009·Current Opinion in Oncology·Matthew C Winter, Robert E Coleman
Jan 13, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Catherine Van PoznakRichard Eastell
Feb 20, 2010·Current Pharmaceutical Design·Ingunn Holen, Robert E Coleman

❮ Previous
Next ❯

Citations

Sep 8, 2012·Clinical & Experimental Metastasis·Louis Doré-SavardPhilippe Sarret
Aug 8, 2018·BMC Musculoskeletal Disorders·Joseph K KendalMichael J Monument
Sep 29, 2018·International Journal of Molecular Sciences·Hannah K BrownIngunn Holen
Jan 1, 2015·BoneKEy Reports·Koen RaymaekersGeert Carmeliet
Dec 11, 2020·Neuro-oncology Practice·Joshua T Wewel, John E O'Toole

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

The Breast : Official Journal of the European Society of Mastology
M Aapro, R E Coleman
European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Carla RipamontiHans Gerdes
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
R E Coleman
Annals of Oncology : Official Journal of the European Society for Medical Oncology
Fatima CardosoESMO Guidelines Working Group
© 2021 Meta ULC. All rights reserved