Advances in management of Guillain-Barré syndrome

Current Opinion in Neurology
Alex Y DoetsP A van Doorn

Abstract

The clinical presentation of Guillain-Barré syndrome (GBS) is highly variable, which can make the diagnosis challenging. Intravenous immunoglobulin (IVIg) and plasma exchange are the cornerstones of treatment since decades. But despite these treatments, 25% initially progress in muscle weakness, 25% require artificial ventilation, 20% is still not able to walk independently after 6 months, and 2-5% die, emphasizing the need for better treatment. We summarize new developments regarding the diagnosis, prognosis, and management of GBS. GBS is a clinical diagnosis that can be supported by cerebrospinal fluid examination and nerve conduction studies. Nerve ultrasound and MRI are potentially useful techniques to diagnose inflammatory neuropathies. Several novel infections have recently been associated to GBS. Evidence from experimental studies and recent phase 2 clinical trials suggests that complement inhibition combined with IVIg might improve outcome in GBS, but further studies are warranted. Prognostic models could guide the selection of patients with a relatively poor prognosis that might benefit most from additional IVIg or otherwise intensified treatment. New diagnostic tools may help to have early and accurate diagnosis in di...Continue Reading

References

Jan 1, 1990·Annals of Neurology·A K Asbury, D R Cornblath
Jan 11, 2008·Brain : a Journal of Neurology·Susan K HalsteadHugh J Willison
Oct 22, 2008·Journal of Neurology, Neurosurgery, and Psychiatry·K KuitwaardP A van Doorn
Sep 22, 2010·Brain : a Journal of Neurology·Norito KokubunNobuhiro Yuki
Sep 24, 2010·Neurology·L RutsUNKNOWN Dutch GBS Study Group
Mar 2, 2011·Neurology·J RoodbolB C Jacobs
Mar 16, 2011·Neurology·C WalgaardB C Jacobs
Dec 14, 2011·Expert Review of Neurotherapeutics·Masahiro MoriNobuhiro Yuki
Feb 7, 2012·Emerging Infectious Diseases·Michael G BakerNick Wilson
Aug 1, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Corine H GeurtsvankesselAlbert D M E Osterhaus
Oct 29, 2013·Brain : a Journal of Neurology·Christiaan FokkeBart Casper Jacobs
Jan 15, 2014·Neurology·Bianca van den BergBart C Jacobs
May 13, 2014·Journal of Neurology, Neurosurgery, and Psychiatry·Yusuf A RajaballyGuillaume Nicolas
May 15, 2015·Journal of Neurology, Neurosurgery, and Psychiatry·José BercianoMaría J Sedano
May 29, 2015·Annals of Neurology·Ruth HuizingaBart C Jacobs
Jul 22, 2015·Scientific Reports·Ryo Takahashi, Nobuhiro Yuki
Dec 30, 2015·Nature Reviews. Neurology·Harry R DaltonBart C Jacobs
Mar 8, 2016·Lancet·Hugh J WillisonPieter A van Doorn
Mar 13, 2016·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Y SekiguchiS Kuwabara
Mar 26, 2016·The Spine Journal : Official Journal of the North American Spine Society·Mustafa ResorluOzan Karatag
Apr 17, 2016·Journal of the Neurological Sciences·Junko IshiiNobuo Kohara
Apr 17, 2016·Journal of the Neurological Sciences·Atsuko MoriRyuji Kaji
May 22, 2016·Journal of the Neurological Sciences·Francesca NotturnoAntonino Uncini
Jul 8, 2016·Annals of Clinical and Translational Neurology·Willem-Jan R FokkinkBart C Jacobs
Jul 9, 2016·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Jiro FukaeYoshio Tsuboi
Aug 5, 2016·Annals of Neurology·Patrick M Meyer SauteurBart C Jacobs
Sep 13, 2016·Journal of the Peripheral Nervous System : JPNS·Mohammad B IslamBart C Jacobs
Nov 1, 2016·The New England Journal of Medicine·Beatriz ParraCarlos A Pardo
Nov 2, 2016·Journal of the Peripheral Nervous System : JPNS·Amy I DavidsonHugh J Willison
Nov 12, 2016·Journal of Neurology, Neurosurgery, and Psychiatry·Christine VerboonBart C Jacobs
Nov 20, 2016·Nature Reviews. Neurology·John A Goodfellow, Hugh J Willison
Dec 15, 2016·Current Neuropharmacology·Nazgol Motamed-GorjiGiovanna Vitaliti
Dec 28, 2016·JAMA Neurology·Richard A C Hughes
Mar 3, 2017·Journal of Neurology·Joyce RoodbolBart C Jacobs
May 4, 2017·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·V KahlmannB C Jacobs
May 19, 2017·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Antonino UnciniSatoshi Kuwabara
Aug 24, 2017·Journal of the Peripheral Nervous System : JPNS·Yuko YamagishiSusumu Kusunoki

❮ Previous
Next ❯

Citations

Apr 30, 2019·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Reda Badry
Mar 7, 2020·Journal of Neurology·Pei ShangHong-Liang Zhang
Oct 1, 2019·Current Opinion in Ophthalmology·Bayan Al OthmanAndrew G Lee
Dec 5, 2019·Academic Pathology·Caitlin J Alexander, Laura M Wake
Feb 9, 2021·Frontiers in Pediatrics·Christina DoxakiPelagia Vorgia
Aug 2, 2021·Critical Care Nurse·Mariah Q RoseWilliam D Freeman
Apr 14, 2020·Journal of the American Association of Nurse Practitioners·Ching-Wen WeiHsin-Huei Chang

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.