Advances in mass spectrometry for lipidomics

Annual Review of Analytical Chemistry
Stephen J Blanksby, Todd W Mitchell

Abstract

Recent expansion in research in the field of lipidomics has been driven by the development of new mass spectrometric tools and protocols for the identification and quantification of molecular lipids in complex matrices. Although there are similarities between the field of lipidomics and the allied field of mass spectrometry (e.g., proteomics), lipids present some unique advantages and challenges for mass spectrometric analysis. The application of electrospray ionization to crude lipid extracts without prior fractionation-the so-called shotgun approach-is one such example, as it has perhaps been more successfully applied in lipidomics than in any other discipline. Conversely, the diverse molecular structure of lipids means that collision-induced dissociation alone may be limited in providing unique descriptions of complex lipid structures, and the development of additional, complementary tools for ion activation and analysis is required to overcome these challenges. In this article, we discuss the state of the art in lipid mass spectrometry and highlight several areas in which current approaches are deficient and further innovation is required.

References

Apr 1, 1974·Biomedical Mass Spectrometry·G W Wood, P Y Lau
Oct 25, 1994·Proceedings of the National Academy of Sciences of the United States of America·X Han, R W Gross
Mar 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·B BrüggerW D Lehmann
Apr 11, 2000·Journal of the American Society for Mass Spectrometry·N Khaselev, R C Murphy
Nov 20, 2001·Chemical Reviews·R C MurphyJ Hevko
Jan 4, 2003·Rapid Communications in Mass Spectrometry : RCM·Yen-Peng HoKuang-Hao Deng
Sep 2, 2003·Mass Spectrometry Reviews·Melissa Pulfer, Robert C Murphy
Mar 17, 2004·Analytical Chemistry·David TouboulOlivier Laprévote
Mar 17, 2004·Analytical Chemistry·Madalina RujoiM Cecilia Yappert
Jun 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·John E P SykaDonald F Hunt
Jul 31, 2004·Analytical Chemistry·Peter SjövallBjörn Johansson
Oct 7, 2004·Journal of the American Society for Mass Spectrometry·Karin A Zemski Berry, Robert C Murphy
Feb 22, 2005·Journal of Lipid Research·Eoin FahyEdward A Dennis
Jul 16, 2005·Journal of the American Society for Mass Spectrometry·Andrew M McAnoyRobert C Murphy
Jul 30, 2005·Nature Reviews. Drug Discovery·Markus R Wenk
Aug 13, 2005·Journal of the American Society for Mass Spectrometry·John C JurchenJonathan V Sweedler
Sep 3, 2005·The EMBO Journal·Gerrit van Meer
Mar 18, 2006·Science·R Graham CooksJustin M Wiseman
Aug 2, 2006·Analytical Chemistry·Michael D Leavell, Julie A Leary
Oct 7, 2006·Free Radical Biology & Medicine·Li HuangDouglas Borchman

❮ Previous
Next ❯

Citations

Dec 29, 2010·Analytical and Bioanalytical Chemistry·Maria Careri, Alessandro Mangia
Oct 16, 2010·Journal of the American Society for Mass Spectrometry·Shane R EllisStephen J Blanksby
Sep 24, 2011·Chemical Reviews·Shankar SubramaniamMano Ram Maurya
May 26, 2011·Cold Spring Harbor Perspectives in Biology·Dominik SchwudkeAndrej Shevchenko
Jan 25, 2012·PloS One·Ronny HerzogAndrej Shevchenko
Feb 8, 2011·Journal of Clinical Biochemistry and Nutrition·Alejandro K Samhan-AriasValerian E Kagan
Apr 25, 2014·Journal of the American Society for Mass Spectrometry·Roberto FernándezJosé A Fernández
Oct 14, 2014·Trends in Analytical Chemistry : TRAC·Tomas Cajka, Oliver Fiehn
Feb 10, 2016·Bioanalysis·Tuulia Hyötyläinen, Matej Orešič
Dec 26, 2015·Progress in Lipid Research·Miao WangXianlin Han
Feb 24, 2016·Proceedings of the National Academy of Sciences of the United States of America·Xiaoxiao MaYu Xia
Apr 20, 2012·Toxicology and Applied Pharmacology·Anna A ShvedovaValerian E Kagan
Mar 3, 2012·Current Opinion in Chemical Biology·H Alex Brown
Jun 28, 2011·Chemistry and Physics of Lipids·Max Scherer, Gerd Schmitz
Jul 13, 2011·Biochimica Et Biophysica Acta·Max SchererGerhard Liebisch
Jun 21, 2011·Biochimica Et Biophysica Acta·David S MyersH Alex Brown
Jun 28, 2011·Biochimica Et Biophysica Acta·Eoin FahyShankar Subramaniam
May 17, 2011·Biochimica Et Biophysica Acta·Simon H J BrownStephen J Blanksby
Mar 26, 2013·Molecular Nutrition & Food Research·Antonin LamazierePeter J Quinn
Jul 22, 2014·Journal of Mass Spectrometry : JMS·Anna Bodzon-KulakowskaPiotr Suder
Sep 3, 2014·Rapid Communications in Mass Spectrometry : RCM·Miao WangXianlin Han
Dec 9, 2015·International Journal of Mass Spectrometry·Robert E DeimlerGlen P Jackson
Jan 15, 2016·Biomedical Chromatography : BMC·Sumitra PatiBrian S Cummings
Sep 10, 2015·Journal of Mass Spectrometry : JMS·Tania PettaLúcia H Faccioli
Apr 30, 2013·Progress in Lipid Research·Shane R EllisTodd W Mitchell
Jul 25, 2015·BMC Neuroscience·Daniele VergaraAnna M Giudetti

❮ Previous
Next ❯

Methods Mentioned

BETA
nuclear magnetic resonance
electron-transfer dissociation
MDS

Software Mentioned

OzID
LASSO
MZmine
SL
AMDMS
MS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Mass Spectrometry Reviews
Melissa Pulfer, Robert C Murphy
Nature Reviews. Molecular Cell Biology
Andrej Shevchenko, Kai Simons
Nature Reviews. Drug Discovery
Markus R Wenk
© 2021 Meta ULC. All rights reserved