Advances in metabolic profiling of experimental nematode and trematode infections

Advances in Parasitology
Yulan WangElaine Holmes

Abstract

Metabonomics, which is the combination of metabolic profiling of biological samples using spectroscopic methods, together with multivariate data analysis, is a powerful approach for biomarker recovery. Moreover, metabonomics holds promise to enhance our understanding of host-parasite interactions at the metabolic level, and therefore provides a framework for discovery of novel targets for diagnostics, drugs and vaccines. In this review, we summarise progress made to date with metabolic profiling strategies applied to different host-parasite models in the laboratory. First, we emphasise the application of two parasitic worm infections that are particularly relevant for Southeast Asia and the People's Republic of China, namely the trematode Schistosoma japonicum causing schistosomiasis, and the nematode Necator americanus causing hookworm disease. Next, we review metabolic profiling studies on the liver fluke Fasciola hepatica in the rat model, the intestinal fluke Echinostoma caproni harboured in mice and characterise the metabolic responses in the hamster to a S. japonicum-N. americanus co-infection. We extract parasite-specific biomarkers and distinguish them from a more general response to an infection at the biochemical leve...Continue Reading

Citations

Jan 8, 2011·The American Journal of Tropical Medicine and Hygiene·Jia V LiOliver Balmer
Aug 5, 2010·Current Opinion in Infectious Diseases·Jennifer KeiserJürg Utzinger
Dec 21, 2019·Scientific Reports·Dominic RitlerBritta Lundström-Stadelmann
Apr 18, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Phurpa WangchukAlex Loukas
May 26, 2018·FEMS Microbiology Ecology·Murad Ali MubarakiMohammed A Marie
Jul 25, 2015·Translational Research : the Journal of Laboratory and Clinical Medicine·Irina LeonardiGerhard Rogler
Jun 16, 2021·Parasites & Vectors·Mingxing ZhuWei Zhao

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