PMID: 9187921Jun 1, 1997Paper

Advances in mucosal immunology

Gastroenterology Clinics of North America
I McGowanD Jewell

Abstract

HIV infection is likely to remain a significant medical and scientific problem well into the twenty-first century. During the first 15 years of the epidemic, much has been learned about the biology of HIV infection, but the majority of biomedical research has focused on the peripheral circulation. It is likely that the behavior of the virus within the unique immunologic environment of the intestinal mucosa differs from that which is observed in the periphery. Many clinical and epidemiologic features of HIV infection offer compelling reasons to encourage further examination of the mucosal immune system's role in AIDS pathogenesis. This article has touched on most of the significant observations concerning the mucosal immune system and HIV infection, and it is clear that much remains to be done. As mentioned earlier, the mucosal abnormalities observed in HIV infection are likely to have many causes. Careful evaluation of patients with early disease and fewer confounding variables may provide fresh insight into AIDS pathogenesis. Similarly, prospective evaluation of selected patient populations may be more informative in characterizing the progressive alterations in mucosal immune function than random cross-sectional studies of po...Continue Reading

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Citations

Apr 5, 2003·Toxicology Letters·C Frieke KuperVictor J Feron
Jan 15, 2000·Journal of Clinical Gastroenterology·H FogaçaC Elia
Nov 13, 2010·Orvosi hetilap·Erzsébet Fehér
Nov 27, 1999·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·S CimermanD S Lewi
Jan 8, 2000·São Paulo Medical Journal = Revista Paulista De Medicina·S CimermanD S Lewi
Jun 23, 2005·Journal of Psycholinguistic Research·Raphiq Ibrahim, Judith Aharon-Peretz
Apr 5, 2007·Arquivos De Gastroenterologia·Christiane Araujo Chaves LeiteUlysses Fagundes-Neto

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