Advances in nanomaterial based optical biosensing and bioimaging of apoptosis via caspase-3 activity: a review

Mikrochimica Acta
Balal KhalilzadehMohammad-Reza Rashidi

Abstract

Caspase-3 plays a vital role in intrinsic and extrinsic pathways of programed cell death and in cell proliferation. Its detection is an important tool for early detection of some cancers and apoptosis-related diseases, and for monitoring the efficacy of pharmaceuticals and of chemo- and radiotherapy of cancers. This review (with 72 references) summarizes nanomaterial based methods for signal amplification in optical methods for the determination of caspase-3 activity. Following an introduction into the field, a first large section covers optical assays, with subsections on luminescent and chemiluminescence, fluorometric (including FRET based), and colorimetric assays. Further section summarize methods for bioimaging of caspase-3. A concluding section covers current challenges and future perspectives. Graphical Abstract ᅟ.

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Citations

Jun 27, 2020·Cancer Biology & Therapy·Chunhua ZhouLulu Zhai
Jul 20, 2019·Molecular Medicine Reports·Xia LiuJianchao Wang
Nov 25, 2019·Mikrochimica Acta·Farzaneh GhorbaniMehdi Yousefi
Sep 4, 2020·International Journal of Molecular Sciences·Nishant S KulkarniVivek Gupta
Mar 11, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Somayeh RezaeiMarjan Motiei
Nov 13, 2019·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Yan CaoZhaofen Zheng
Jan 1, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jianming HuangHaoyuan Liu
Oct 31, 2020·International Journal of Biological Macromolecules·Zahra KarimzadehBalal Khalilzadeh
Jul 23, 2021·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Tao LiuChunwei Lan

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