Advances in natural stable isotope ratio analysis of human hair to determine nutritional and metabolic status

Current Opinion in Clinical Nutrition and Metabolic Care
Klaus J PetzkeCornelia C Metges

Abstract

We review the literature on the use of stable isotope ratios at natural abundance to reveal information about dietary habits and specific nutrient intakes in human hair protein (keratin) and amino acids. In particular, we examine whether hair isotopic compositions can be used as unbiased biomarkers to provide information about nutritional status, metabolism, and diseases. Although the majority of research on the stable isotope ratio analysis of hair has focused on bulk protein, methods have been recently employed to examine amino acid-specific isotope ratios using gas chromatography or liquid chromatography coupled to an isotope ratio mass spectrometer. The isotopic measurement of amino acids has the potential to answer research questions on amino acid nutrition, metabolism, and disease processes and can contribute to a better understanding of the variations in bulk protein isotope ratio values. First results suggest that stable isotope ratios are promising as unbiased nutritional biomarkers in epidemiological research. However, variations in stable isotope ratios of human hair are also influenced by nutrition-dependent nitrogen balance, and more controlled clinical research is needed to examine these effects in human hair. Sta...Continue Reading

References

Nov 1, 1991·The Journal of Nutrition·K Y Guggenheim
Jun 1, 1997·American Journal of Physical Anthropology·C D White, G J Armelagos
Mar 26, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·S A MackoR E Hedges
May 6, 1999·American Journal of Physical Anthropology·T C O'Connell, R E Hedges
Jun 23, 1999·Journal of Chromatography. a·W Meier-Augenstein
Mar 27, 2001·Rapid Communications in Mass Spectrometry : RCM·R A Werner, W A Brand
Nov 1, 2002·Phytochemistry·Roland A Werner, Hanns Ludwig Schmidt
Nov 21, 2002·Rapid Communications in Mass Spectrometry : RCM·Roland Bol, Christian Pflieger
Nov 29, 2002·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Jonathan H Williams, Tamsin C O'Connell
Mar 4, 2003·The Journal of Nutrition·Nancy Potischman
Jun 18, 2003·Rapid Communications in Mass Spectrometry : RCM·Michael SchwertlHans Schnyder
Jun 3, 2004·The Journal of Nutrition·Padma Maruvada, Sudhir Srivastava
Sep 24, 2004·Rapid Communications in Mass Spectrometry : RCM·Michael KrummenReinhold Pesch
Nov 2, 2004·Rapid Communications in Mass Spectrometry : RCM·Benjamin T FullerRobert E M Hedges
Apr 30, 2005·Analytical Chemistry·Gavin L Sacks, J Thomas Brenna
May 10, 2005·Rapid Communications in Mass Spectrometry : RCM·Klaus J PetzkeCornelia C Metges
May 28, 2005·Forensic Science International : Synergy·Sarah BensonClaude Roux
Aug 18, 2005·Rapid Communications in Mass Spectrometry : RCM·Benjamin T FullerRobert E M Hedges
Oct 13, 2005·Rapid Communications in Mass Spectrometry : RCM·James S O McCullaghRobert E M Hedges
Nov 2, 2005·American Journal of Physical Anthropology·B T FullerR E M Hedges
Sep 7, 2006·Rapid Communications in Mass Spectrometry : RCM·Klaus J PetzkeCornelia C Metges
Sep 15, 2006·Journal of Separation Science·Alex L Sessions
Oct 18, 2006·Rapid Communications in Mass Spectrometry : RCM·Kent A HatchBeverly L Roeder
Dec 13, 2006·The American Journal of Clinical Nutrition·A Hope JahrenBenjamin Caballero
May 9, 2007·Analytical and Bioanalytical Chemistry·Frank Musshoff, Burkhard Madea
Jul 5, 2007·Rapid Communications in Mass Spectrometry : RCM·Diane M O'Brien, Matthew J Wooller
Sep 14, 2007·Mass Spectrometry Reviews·Jean-Philippe GodinGérard Hopfgartner
Jan 31, 2008·Rapid Communications in Mass Spectrometry : RCM·Lin Zhang, Mark A Altabet
Feb 27, 2008·Proceedings of the National Academy of Sciences of the United States of America·James R EhleringerThure E Cerling
Sep 25, 2008·International Journal of Legal Medicine·Elisabeth Mützel RauchAndreas Rossmann
Oct 28, 2008·Rapid Communications in Mass Spectrometry : RCM·Rebecca A KraftChristopher D Saudek
Oct 29, 2008·Science & Justice : Journal of the Forensic Science Society·Wolfram Meier-Augenstein, Isla Fraser
Dec 3, 2008·Biological Reviews of the Cambridge Philosophical Society·Carlos Martínez del RioLeonard Z Gannes
Jan 1, 2009·Experimental Biology and Medicine·Julie A HoweSherry A Tanumihardjo
Jan 29, 2009·The Analyst·Zeland Muccio, Glen P Jackson
Jan 30, 2009·The American Journal of Clinical Nutrition·Diane M O'BrienBret Luick
Feb 5, 2009·Isotopes in Environmental and Health Studies·Robert HedgesWilliam Aalbersberg

❮ Previous
Next ❯

Citations

Jul 9, 2011·International Journal of Legal Medicine·Christine LehnAndreas Rossmann
Mar 9, 2012·Pediatric Research·Arnaud de LucaRégis Hankard
Sep 21, 2011·PloS One·Stephanie J PietschThomas Tütken
May 6, 2014·Oecologia·Christopher H RemienThure E Cerling
Dec 3, 2014·Journal of Theoretical Biology·Christopher H Remien
Aug 5, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jong-Ku ParkYeon-Sik Bong
Jul 11, 2012·Rapid Communications in Mass Spectrometry : RCM·William M Hagopian, A Hope Jahren
Jan 5, 2012·Rapid Communications in Mass Spectrometry : RCM·Tobias DeschnerGottfried Hohmann
Jul 24, 2015·American Journal of Human Biology : the Official Journal of the Human Biology Council·Laurie J Reitsema
Oct 9, 2015·Ecology and Evolution·Ivan CalandraNicolas Navarro
Nov 5, 2014·American Journal of Human Biology : the Official Journal of the Human Biology Council·Ayako MoritaMasahiro Umezaki
Sep 26, 2015·Rapid Communications in Mass Spectrometry : RCM·Joshua N BosticA Hope Jahren
Jan 13, 2015·Science & Justice : Journal of the Forensic Science Society·Glen P JacksonAyat H B Rashaid
Jun 7, 2015·Annual Review of Nutrition·Diane M O'Brien
Jan 13, 2015·Science & Justice : Journal of the Forensic Science Society·Christine LehnMatthias Graw
Jan 8, 2017·Rapid Communications in Mass Spectrometry : RCM·Thuan H ChauLesley A Chesson
Mar 16, 2017·Isotopes in Environmental and Health Studies·Frank HülsemannWilhelm Schänzer
May 4, 2017·Rapid Communications in Mass Spectrometry : RCM·Frank HülsemannWilhelm Schänzer
Feb 2, 2018·American Journal of Human Biology : the Official Journal of the Human Biology Council·Luciano O ValenzuelaJames R Ehleringer
Jul 3, 2018·Biological & Pharmaceutical Bulletin·Yohei HottaTetsuya Endo
Mar 4, 2015·The American Journal of Clinical Nutrition·Nita G ForouhiTamsin C O'Connell
Aug 5, 2020·Proceedings of the National Academy of Sciences of the United States of America·James R EhleringerThure E Cerling
Mar 4, 2015·The American Journal of Clinical Nutrition·Klaus J Petzke
Jan 3, 2021·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Hideki OgasawaraTetsuya Endo
Aug 29, 2020·Forensic Science International : Synergy·Saskia AmmerEugénia Cunha
Jul 3, 2021·Metabolites·Illa TeaGuillaume Tcherkez

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.