May 9, 2019

Advances in our understanding of genetic kidney disease using kidney organoids

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Melissa H Little, Catherine Quinlan

Abstract

A significant proportion of kidney disease presenting in childhood is likely genetic in origin with a growing number of genes implicated in its development. However, many children may have changes in previously undescribed or unrecognised genes. The recent development of methods for generating human kidney organoids from human pluripotent stem cells has the potential to substantially change the rate of diagnosis and the development of new treatments for some forms of genetic kidney disease. In this review, we discuss how accurately a kidney organoid models the human kidney, identifying the strengths and weaknesses of these potentially patient-derived models of renal disease.

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Citations

Mentioned in this Paper

Pluripotent Stem Cells
Genes
Kidney
Organoids
Kidney Diseases
Urologic Diseases

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