PMID: 16524538Mar 10, 2006Paper

Advances in pharmacologic agents in imaging: new A2A receptor agonists

Current Cardiology Reports
Manuel D Cerqueira

Abstract

Pharmacologic stress myocardial perfusion imaging is being performed with increasing frequency over exercise stress. Dipyridamole and adenosine have a high side-effect profile, provide higher than needed coronary artery flow rates, and use a relatively complicated method of administration. Based on preclinical animal work, three selective adenosine A2A receptor agonists, regadenoson (CVT3146), binodenoson (MRE0470 or WRC0470), and apadenoson (BMS068645 or ATL146e), may overcome these limitations and are now in Phase III studies as pharmacologic stress agents. For single-photon emission CT imaging, binodenoson and regadenoson were concordant with adenosine images for detection and quantitation of ischemia. Despite the high A2A selectivity of binodenoson and regadenoson in preclinical studies, subjective side effects attributable to other adenosine receptor subtypes were still observed in human studies and are similar to or slightly lower than adenosine. There have been no reports of atrioventricular block or bronchospasm with either regadenoson or binodenoson in published trials.

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Citations

Nov 27, 2007·Naunyn-Schmiedeberg's Archives of Pharmacology·Prabal K Chatterjee
Jul 17, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Carlos Salgado GarciaIgnacio Ynfante Milá
Feb 5, 2008·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Eva FrickeOliver Lindner
Sep 26, 2013·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Sujethra VasuAndrew E Arai
Sep 19, 2007·Expert Opinion on Emerging Drugs·Zhan-Guo Gao, Kenneth A Jacobson
Aug 23, 2011·Pharmacological Reports : PR·Monika Samsel, Krystyna Dzierzbicka
Dec 31, 2015·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Gregory S ThomasMichael Safani
Dec 28, 2010·Biochimica Et Biophysica Acta·Christa E Müller, Kenneth A Jacobson
Sep 19, 2009·Journal of the American College of Cardiology·Wael Al Jaroudi, Ami E Iskandrian
Mar 11, 2008·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Ross J McGeoch, Keith G Oldroyd
Nov 2, 2017·Cadernos de saúde pública·Noris García-JordánWilfredo Quiñones
Apr 10, 2012·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Bruce M PrennerBruce E McNutt
Oct 30, 2013·Journal of Medicinal Chemistry·Manuel de Lera RuizJunying Zheng

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