Advances in proline ligation.

Journal of the American Chemical Society
Steven D TownsendSamuel J Danishefsky

Abstract

Application of native chemical ligation logic to the case of an N-terminal proline is described. Two approaches were studied. One involved incorporation of a 3R-substituted thiyl-proline derivative. Improved results were obtained from a 3R-substituted selenol function, incorporated in the context of an oxidized dimer.

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