Advances in prostate-specific membrane antigen PET of prostate cancer

Current Opinion in Oncology
Kirsten Bouchelouche, Peter Choyke

Abstract

In recent years, a large number of reports have been published on prostate-specific membrane antigen (PSMA)/PET in prostate cancer (PCa). This review highlights advances in PSMA PET in PCa during the past year. PSMA PET/computed tomography (CT) is useful in detection of biochemical recurrence, especially at low prostate-specific antigen (PSA) values. The detection rate of PSMA PET is influenced by PSA level. For primary PCa, PSMA PET/CT shows promise for tumour localization in the prostate, especially in combination with multiparametric MRI (mpMRI). For primary staging, PSMA PET/CT can be used in intermediate and high-risk PCa. Intraoperative PSMA radioligand guidance seems promising for detection of malignant lymph nodes. While the use of PSMA PET/MRI in primary localized disease is limited to high and intermediate-risk patients and localized staging, in the recurrence setting, PET/MRI can be particularly helpful when the lesions are subtle. PSMA PET/CT is superior to choline PET/CT and other conventional imaging modalities. Molecular imaging with PSMA PET continues to pave the way for personalized medicine in PCa.However, large prospective clinical studies are still needed to fully evaluate the role of PSMA PET/CT and PET/MRI...Continue Reading

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Citations

Nov 30, 2018·Asia-Pacific Journal of Clinical Oncology·Oliver Sartor
Nov 7, 2019·World Journal of Urology·Y Hess-BuschJ Hess
Mar 21, 2020·Current Opinion in Oncology·Mohammad Amin HadavandMohummad Minhaj Siddiqui
Dec 13, 2018·Clinical Nuclear Medicine·Søren KlingenbergKirsten Bouchelouche
Feb 9, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Ana Margarida AbrantesMaria Filomena Botelho
Dec 21, 2020·European Journal of Nuclear Medicine and Molecular Imaging·L PappM Hacker
May 4, 2018·Science Translational Medicine·Hao G NguyenDavide Ruggero

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