Advances in proton therapy in lung cancer

Therapeutic Advances in Respiratory Disease
Melissa A L VyfhuisCharles B Simone

Abstract

Lung cancer remains the leading cause of cancer deaths in the United States (US) and worldwide. Radiation therapy is a mainstay in the treatment of locally advanced non-small cell lung cancer (NSCLC) and serves as an excellent alternative for early stage patients who are medically inoperable or who decline surgery. Proton therapy has been shown to offer a significant dosimetric advantage in NSCLC patients over photon therapy, with a decrease in dose to vital organs at risk (OARs) including the heart, lungs and esophagus. This in turn, can lead to a decrease in acute and late toxicities in a population already predisposed to lung and cardiac injury. Here, we present a review on proton treatment techniques, studies, clinical outcomes and toxicities associated with treating both early stage and locally advanced NSCLC.

References

Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·J M SlaterJ D Slater
Nov 13, 1999·Chest·D A BushJ M Slater
Apr 16, 2003·International Journal of Radiation Oncology, Biology, Physics·Yoshiyuki ShioyamaKiyohisa Sekizawa
Oct 16, 2004·Chest·David A BushJames M Slater
Feb 7, 2006·International Journal of Radiation Oncology, Biology, Physics·Keiji NiheiHideki Nishimura
Apr 4, 2006·International Journal of Radiation Oncology, Biology, Physics·Martijn EngelsmanHanne M Kooy
Oct 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert TimmermanJames Fletcher
Mar 24, 2007·International Journal of Radiation Oncology, Biology, Physics·Masaharu HataYasuyuki Akine
Jan 18, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Francesca AlbertiniGudrun Goitein
Jan 27, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Si Yeol SongEun Kyung Choi
Apr 17, 2009·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Changlu WangKoichi Tokuuye
Jan 9, 2010·International Journal of Radiation Oncology, Biology, Physics·Hidetsugu NakayamaKoichi Tokuuye
Jan 13, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Inga S GrillsLarry L Kestin
Jul 20, 2010·International Journal of Radiation Oncology, Biology, Physics·Hiroshi OnishiTsutomu Araki
Jul 24, 2010·Seminars in Radiation Oncology·Joe Y Chang, James D Cox
Oct 5, 2010·International Journal of Radiation Oncology, Biology, Physics·Hidetsugu NakayamaKoichi Tokuuye
Oct 23, 2010·Medical Physics·Takuji FurukawaKoji Noda
Nov 3, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David PalmaSuresh Senan
Apr 30, 2011·Chinese Journal of Cancer·Hui Liu, Joe Y Chang
Jul 16, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·M BaumannUNKNOWN CHARTWEL-Bronchus studygroup
Sep 10, 2011·Journal of the National Cancer Institute·Walter J CurranJames D Cox
Nov 11, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Erik RoelofsUNKNOWN ROCOCO Consortium
Dec 14, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Yoshiko OshiroHideyuki Sakurai
May 1, 2012·International Journal of Radiation Oncology, Biology, Physics·Eugene J KoayJoe Y Chang
Jul 31, 2012·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Inga Siiner GrillsJose Belderbos
Sep 15, 2012·International Journal of Radiation Oncology, Biology, Physics·Shervin M ShirvaniBenjamin D Smith
Mar 6, 2013·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Hiromitsu IwataNobukazu Fuwa
Mar 7, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Sashendra SenthiSuresh Senan
Sep 11, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Sarah A McAvoyDaniel R Gomez
Oct 22, 2013·Journal of Radiation Research·Shinichiro MoriGeorge T Y Chen
May 28, 2014·Journal of Radiation Research·Yoshiko OshiroHideyuki Sakurai
Oct 12, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J MaguireM Snee
Nov 22, 2014·The Cancer Journal·Charles B Simone, Ramesh Rengan

❮ Previous
Next ❯

Citations

Apr 10, 2020·Journal of Medical Imaging and Radiation Oncology·Eun Ji HwangVerity Ahern
Oct 30, 2020·Expert Review of Anticancer Therapy·Nirav V PatelPranshu Mohindra
May 31, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Stephen R BowenJing Zeng
Dec 29, 2020·Journal of Applied Clinical Medical Physics·Minglei KangHaibo Lin
Mar 12, 2021·Seminars in Thoracic and Cardiovascular Surgery·Mary McGunigalPuja Gaur Khaitan
Nov 11, 2020·Zeitschrift für medizinische Physik·Hatice Selcen DumluMarco Riboldi
May 17, 2021·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Yabo FuXiaofeng Yang
Aug 25, 2021·Doklady. Biochemistry and Biophysics·V E BalakinN S Strelnikova

❮ Previous
Next ❯

Methods Mentioned

BETA
surgical resection

Clinical Trials Mentioned

NCT01993810
NCT00875901

Software Mentioned

IMPT
CHARTWEL

Related Concepts

Related Feeds

Cardiotoxicity

Cardiotoxicity refers to the muscle damage or dysfunction of heart electrophysiology caused by drug intake or due to disease complications. It is a well-known side effect of several cytotoxic drugs, especially of the anthracyclines and can lead to long term morbidity. Here is the latest research.

Related Papers

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
Kenneth D WestoverHenning Willers
Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Sol San JoséFerran Guedea
© 2022 Meta ULC. All rights reserved