Advances in psychopharmacology: mood disorders and dementia

British Medical Bulletin
Philip J Cowen

Abstract

Recent years have seen the introduction of several new antidepressants, many of which have selective effects on serotonin (5-HT) pathways. In most patients these drugs are as effective as traditional tricyclic antidepressants and are somewhat better tolerated. In the most severe depressive disorders, however, drugs such as clomipramine, that produce potent inhibition of both 5-HT and noradrenaline reuptake may be more effective. Lithium is increasingly used in the treatment of resistant depression but its role in the short-term management of mania is less certain because of the increased risk of relapse on sudden discontinuation. In the treatment of mania and prophylaxis of bipolar disorder, carbamazepine and valproate are alternatives to lithium. In dementia, the cholinesterase inhibitor, tacrine, produces worthwhile improvement in about 40% of patients able to tolerate adequate doses. There is concern about adverse effects of antipsychotic drugs in patients with dementia, particularly those with Lewy body disease.

Citations

Mar 16, 2006·Psychopharmacology·S DevarajanS M Dursun
Sep 3, 2002·Journal of Affective Disorders·A P Van AmerongenA Tournoux
Jun 29, 2005·Journal of Psychopharmacology·S Devarajan, S M Dursun
Jul 13, 2001·Journal of Psychopharmacology·S M DursunS Kutcher
Feb 10, 2000·Journal of Psychopharmacology·P M Grasby
Jul 1, 2010·The Journal of Comparative Neurology·Wenyu FuTomas Hökfelt

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