Advances in radiotherapy techniques and delivery for non-small cell lung cancer: benefits of intensity-modulated radiation therapy, proton therapy, and stereotactic body radiation therapy

Translational Lung Cancer Research
Tejan P DiwanjiShahed N Badiyan

Abstract

The 21st century has seen several paradigm shifts in the treatment of non-small cell lung cancer (NSCLC) in early-stage inoperable disease, definitive locally advanced disease, and the postoperative setting. A key driver in improvement of local disease control has been the significant evolution of radiation therapy techniques in the last three decades, allowing for delivery of definitive radiation doses while limiting exposure of normal tissues. For patients with locally-advanced NSCLC, the advent of volumetric imaging techniques has allowed a shift from 2-dimensional approaches to 3-dimensional conformal radiation therapy (3DCRT). The next generation of 3DCRT, intensity-modulated radiation therapy and volumetric-modulated arc therapy (VMAT), have enabled even more conformal radiation delivery. Clinical evidence has shown that this can improve the quality of life for patients undergoing definitive management of lung cancer. In the early-stage setting, conventional fractionation led to poor outcomes. Evaluation of altered dose fractionation with the previously noted technology advances led to advent of stereotactic body radiation therapy (SBRT). This technique has dramatically improved local control and expanded treatment option...Continue Reading

Citations

Jul 18, 2018·Therapeutic Advances in Respiratory Disease·Melissa A L VyfhuisCharles B Simone
Aug 28, 2020·Frontiers in Oncology·Joshua T BurgessEmma Bolderson
Oct 30, 2020·Expert Review of Anticancer Therapy·Nirav V PatelPranshu Mohindra
Oct 30, 2020·Physics in Medicine and Biology·Cássia O RibeiroArturs Meijers
Dec 29, 2020·Physics in Medicine and Biology·Xingyu NieGuang Li
Mar 12, 2021·Seminars in Thoracic and Cardiovascular Surgery·Mary McGunigalPuja Gaur Khaitan
Apr 24, 2021·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Lokesh KhannaVenkata S Katabathina
Jul 1, 2020·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Moataz RedaWassana Yantasee

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