Advances in Research on the circRNA-miRNA-mRNA Network in Coronary Heart Disease Treated with Traditional Chinese Medicine

Evidence-based Complementary and Alternative Medicine : ECAM
Fei LinChao Liu

Abstract

There has been an increase in morbidity and mortality related to coronary heart disease (CHD) in China in recent years. Numerous clinical experiences and studies have shown that traditional Chinese medicine (TCM) plays an important role in the prevention, treatment, and prognosis of CHD. However, the mechanism of TCM in the treatment of CHD has not yet been elucidated. The circRNA-miRNA-mRNA network consists of miRNA that is competitively bound by circRNA, and miRNA regulates the transcription level of mRNA. Through literature review, we found that the circRNA-miRNA-mRNA network acts to contribute to certain effects to CHD such as myocardial hypertrophy, myocardial fibrosis, and heart failure. TCM contains constituents that act against CHD by antiatherosclerosis and apoptosis inhibition action, cardiac and cardiomyocyte protection, and these components also promote cell growth and protection of the vascular system by regulating miRNAs. Therefore, we consider that the circRNA-miRNA-mRNA network may be a new regulatory mechanism for the effective treatment of CHD by TCM.

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Citations

May 19, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Fei LinGuoan Zhao
Dec 19, 2020·Frontiers in Cell and Developmental Biology·Chaohua JiangRenhua Wan
Oct 27, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Li ZhuGuoan Zhao

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Software Mentioned

CircNfix
ceRNA

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