Advances in Screening and Development of Therapeutic Aptamers Against Cancer Cells.

Frontiers in Cell and Developmental Biology
Zheng LiChao Liang

Abstract

Cancer has become the leading cause of death in recent years. As great advances in medical treatment, emerging therapies of various cancers have been developed. Current treatments include surgery, radiotherapy, chemotherapy, immunotherapy, and targeted therapy. Aptamers are synthetic ssDNA or RNA. They can bind tightly to target molecules due to their unique tertiary structure. It is easy for aptamers to be screened, synthesized, programmed, and chemically modified. Aptamers are emerging targeted drugs that hold great potentials, called therapeutic aptamers. There are few types of therapeutic aptamers that have already been approved by the US Food and Drug Administration (FDA) for disease treatment. Now more and more therapeutic aptamers are in the stage of preclinical research or clinical trials. This review summarized the screening and development of therapeutic aptamers against different types of cancer cells.

References

Aug 30, 1990·Nature·A D Ellington, J W Szostak
Oct 25, 1990·Nucleic Acids Research·M EspelundK S Jakobsen
Jul 1, 1994·Journal of Virology·M S Lechner, L A Laimins
Mar 11, 2003·Nucleic Acids Research·Krithika SubramanianRichard S Myers
Oct 10, 2006·Chemical Communications : Chem Comm·Prabodhika MallikaratchyWeihong Tan
Jul 4, 2007·International Immunology·Taku Okazaki, Tasuku Honjo
Sep 9, 2008·Nucleic Acids Symposium Series·Christian MaaschSven Klussmann
Aug 7, 2009·Molecular Pharmacology·Sridharan SoundararajanDaniel J Fernandes
Mar 9, 2010·Virology·Hans-Ulrich BernardEthel-Michele de Villiers
May 21, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Beverly A Teicher, Simon P Fricker
Nov 26, 2010·Nature Nanotechnology·Peixuan Guo
Jan 18, 2011·Biochemical and Biophysical Research Communications·Clare NicolNicola J Stonehouse
Feb 26, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Dan G DudaRakesh K Jain
Sep 29, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Twan LammersGert Storm
Jan 10, 2013·Molecular Therapy. Nucleic Acids·Congsheng ChengBeverly L Davidson
Mar 21, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Yu Jin LeePann-Ghill Suh
May 1, 2013·Proceedings of the National Academy of Sciences of the United States of America·Georg MahlknechtYosef Yarden
Nov 19, 2013·Investigational New Drugs·Jonathan E RosenbergDamian A Laber
Jun 16, 2014·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Thomas J PovsicRoxana Mehran
Jun 24, 2014·Molecular Therapy : the Journal of the American Society of Gene Therapy·Justin P DassiePaloma H Giangrande
Oct 9, 2014·PloS One·Suzanne C SimmonsSotiris Missailidis
Mar 31, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Edgar Pérez-Herrero, Alberto Fernández-Medarde
Jan 6, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Uwe HaberkornMichael Eisenhut
Jan 6, 2016·Molecular Therapy. Nucleic Acids·Eva M García-RecioVíctor M González
Feb 27, 2016·Current Opinion in Structural Biology·Amy D GelinasNebojsa Janjic
Apr 28, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Hui YuFred R Hirsch
Nov 4, 2016·Nature Reviews. Drug Discovery·Jiehua Zhou, John Rossi
Dec 14, 2016·Molecular Therapy. Nucleic Acids·Wei-Yun LaiPan-Chyr Yang
Dec 23, 2016·Biochimica Et Biophysica Acta. General Subjects·Paula J BatesJohn O Trent
Jan 14, 2017·Molecular Oncology·Daniele V F TaurielloEduard Batlle
Mar 24, 2017·Journal of Cellular Biochemistry·Michael Dougan, Stephanie K Dougan
Jul 4, 2017·British Journal of Haematology·Johannes M WaldschmidtMonika Engelhardt
Nov 8, 2017·Theranostics·Gang ZhouLiang Qiao
Nov 15, 2017·Journal of Nanobiotechnology·Mei LiuNongyue He
Nov 25, 2017·Journal of Applied Microbiology·N AlizadehH Samadi Kafil
Dec 1, 2017·International Journal of Molecular Sciences·Andrew B KinghornJulian A Tanner
Dec 29, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Irene VirgoliniChristian Uprimny

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