Advances in self-assembled injectable hydrogels for cancer therapy

Biomaterials Science
Sandeep Kumar, Avinash Bajaj

Abstract

Non-specific toxicity of chemotherapeutics and evolution of malignant tumors against them are major challenges for existing cancer chemotherapeutic regimens. Engineering of nanomaterials has attempted to minimize the toxicity of anticancer drugs, but systemic delivery of these nanomaterials still imposes many hurdles in their clinical use like burst release of chemotherapeutics and toxicity and immunogenicity associated with excipients of nanomaterials. However, there has been a surge in the development of natural and synthetic nanomaterials to deliver anticancer agents to the diseased (tumor) site as it can minimize the systemic circulation of anticancer drugs and reduce the toxicity-related challenges. Therefore, localized drug delivery is considered as the most effective way to deliver therapeutics but is further challenged by poor biodegradability, high immunogenicity, poor drug entrapment efficacy and inability to maintain sustained release of anticancer agents at the tumor site. This review maps out recent advancements in engineering of low molecular weight hydrogels derived from amino acid, fatty acyl, steroidal lipid and drug conjugated amphiphilic scaffolds. We have summarized the efforts for the development of molecul...Continue Reading

References

Aug 12, 1971·The New England Journal of Medicine·J Folkman
Apr 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·S ZhangA Rich
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Mar 20, 2004·Science·Theresa M Allen, Pieter R Cullis
Dec 2, 2004·Journal of the American Chemical Society·Samrat MukhopadhyayYeshayahu Talmon
Jan 5, 2005·Nature Reviews. Cancer·Bruce A Chabner, Thomas G Roberts
Oct 8, 2005·Organic & Biomolecular Chemistry·Ponnusamy BabuUday Maitra
Jul 14, 2006·The Journal of Physical Chemistry. B·Victor Hugo Soto TelliniJosé Vázquez Tato
Jul 21, 2006·The Journal of Physical Chemistry. B·Pierre TerechUday Maitra
Sep 12, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yusuke NagaiShuguang Zhang
Oct 9, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Sangita RoyPrasanta Kumar Das
Oct 26, 2007·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marco CalabresiCamillo La Mesa
Oct 30, 2007·ChemMedChem·Felix KratzAndré Warnecke
May 8, 2009·Chemical Society Reviews·Fan ZhaoBing Xu
Aug 28, 2009·The Journal of Physical Chemistry. B·Jishu NaskarArindam Banerjee
Apr 13, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Trilochan PatraJoykrishna Dey
May 15, 2010·Chemical Communications : Chem Comm·Hui Shao, Jon R Parquette
Aug 17, 2010·ACS Applied Materials & Interfaces·Xiao-Ding XuRen-Xi Zhuo
Dec 9, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Fan ZhaoBing Xu
Mar 1, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Amrita Pal, Joykrishna Dey
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Mar 16, 2011·Journal of Biomedical Materials Research. Part a·Praveen Kumar VemulaJeffrey M Karp
May 18, 2011·Journal of Colloid and Interface Science·Shlomo Zarzhitsky, Hanna Rapaport
Nov 15, 2011·Chemical Communications : Chem Comm·Lina MaoZhimou Yang
Dec 14, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jesse B WolinskyMark W Grinstaff
Jun 15, 2013·Oxidative Medicine and Cellular Longevity·Nicola TraversoCinzia Domenicotti
Jul 13, 2013·The Journal of Physical Chemistry. B·Leana TravagliniLuciano Galantini
Aug 31, 2013·Organic & Biomolecular Chemistry·Chengbiao YangZhimou Yang
Sep 26, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·M Chiara di GregorioLuciano Galantini
Jul 11, 2014·Chemical Communications : Chem Comm·Chengbiao YangZhimou Yang
Aug 15, 2014·Science Translational Medicine·Thusitha GajanayakeEsther Vögelin
Aug 26, 2014·International Journal of Pharmaceutics·Maria-Lucia BriugliaDimitrios A Lamprou
Aug 14, 2015·Science Translational Medicine·Sufeng ZhangJeffrey M Karp
Sep 9, 2015·Nature Biotechnology·Elvin BlancoMauro Ferrari
Feb 26, 2016·Biomaterials Science·Jessie E P SunDarrin J Pochan

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Citations

Oct 20, 2020·Advanced Healthcare Materials·Fabio Rizzo, Nermin Seda Kehr
Feb 14, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Juliana S YonedaRosangela Itri
Feb 12, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zongyu XieXiaojing Wang
Jan 6, 2021·Gels·Ali DehshahriVijay Kumar Thakur
Jan 15, 2021·International Journal of Nanomedicine·Weipeng WeiFushan Tang
Mar 31, 2021·International Journal of Biological Macromolecules·Shuai LiuMuhammad Bilal
Apr 21, 2021·Macromolecular Rapid Communications·Chunxiang MoYuping Chen
May 21, 2021·Advanced Drug Delivery Reviews·Zhenghao ZhangXingyi Li
Aug 8, 2021·International Journal of Molecular Sciences·Adéla Tiffner, Isabella Derler

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Methods Mentioned

BETA
xenograft
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