Advances in spotted microarray resources for expression profiling

Briefings in Functional Genomics & Proteomics
Paul Lyons

Abstract

The new millennium has ushered in a new era in human biology. The elucidation of the human genome sequence, together with those of model organisms, provides us with an unprecedented insight into the makeup of our genetic blueprint. The challenge now is to figure out how all the constituent pieces fit together to form the whole picture, and the consequences of what happens when the process goes awry. One experimental tool that has the potential to provide enormous insights into this complex process is expression profiling using microarrays. The past few years have seen a considerable growth in the availability and use of microarrays. Fuelled in part by the many genome projects currently underway, there has been a large increase in the number of organisms for which microarray reagents are available from both commercial and academic sources. In addition to the increasing number of genome-wide probe sets that are available, a significant amount of attention has been focussed on generating more targeted probe sets that focus in on specific pathways or biological processes. Finally, the microarray field is starting to see a shift away from the use of cDNAs or polymerase chain reaction (PCR) products as probes towards the use of 50-70...Continue Reading

Citations

Aug 7, 2013·Seminars in Cell & Developmental Biology·Marco-Antonio Mendoza-Parra, Hinrich Gronemeyer
Nov 18, 2009·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Jonathan G FryePaula J Fedorka-Cray
Nov 3, 2009·Diagnostic Microbiology and Infectious Disease·Tavan JanvilisriYung-Fu Chang
Jan 18, 2008·The Journal of Investigative Dermatology·Mei YuKevin J McElwee
Jul 25, 2008·Reproduction in Domestic Animals = Zuchthygiene·A C O EvansT Fair
Jan 24, 2006·International Journal of Antimicrobial Agents·Jonathan G FryePaula J Fedorka-Cray

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