Advances in stem cell therapy for amyotrophic lateral sclerosis

Expert Opinion on Biological Therapy
Letizia MazziniBIONECA COST ACTION WG Neurology

Abstract

Amyotrophic Lateral Sclerosis (ALS) is a progressive, incurable neurodegenerative disease that targets motoneurons. Cell-based therapies have generated widespread interest as a potential therapeutic approach but no conclusive results have yet been reported either from pre-clinical or clinical studies. Areas covered: This is an integrated review of pre-clinical and clinical studies focused on the development of cell-based therapies for ALS. We analyze the biology of stem cell treatments and results obtained from pre-clinical models of ALS and examine the methods and the results obtained to date from clinical trials. We discuss scientific, clinical, and ethical issues and propose some directions for future studies. Expert opinion: While data from individual studies are encouraging, stem-cell-based therapies do not yet represent a satisfactory, reliable clinical option. The field will critically benefit from the introduction of well-designed, randomized and reproducible, powered clinical trials. Comparative studies addressing key issues such as the nature, properties, and number of donor cells, the delivery mode and the selection of proper patient populations that may benefit the most from cell-based therapies are now of the essen...Continue Reading

References

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Citations

Mar 25, 2020·Cell Transplantation·Svitlana Garbuzova-DavisCesario V Borlongan
Apr 14, 2020·Current Topics in Medicinal Chemistry·Sreyashi ChandraPrem P Tripathi
Apr 9, 2020·Frontiers in Neuroscience·Emilio Geijo-BarrientosSalvador Martínez
Sep 17, 2019·World Journal of Stem Cells·Sara CrucianiMargherita Maioli
Oct 17, 2019·International Journal of Molecular Sciences·Francesca BalzanoMargherita Maioli
Mar 3, 2020·Physiological Research·S CrucianiM Maioli
Apr 3, 2021·Npj Regenerative Medicine·Cynthia Morata-TarifaRosario Sanchez-Pernaute
Jul 1, 2020·Current Stem Cell Research & Therapy·Tahereh EbrahimiSoheila Montazersaheb

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