Advances in synthetic dynamic circuits design: using novel synthetic parts to engineer new generations of gene oscillations

Current Opinion in Biotechnology
Steven William SowaLydia Maria Contreras

Abstract

As bioengineering applications expand, the need to design and implement circuits that exhibit dynamic properties increases. In particular, schemes that control precise patterns of gene expression as a function of time are essential for balancing multiple metabolic objectives in natural and synthetic systems. Given that modularity has been an important component of dynamic circuits, recent efforts to improve dynamic circuits have focused on replacing old parts for new components that increase the robustness, stability, and tunability. In this review, we show that incorporation of novel components such as regulatory noncoding RNAs (ncRNAs), promoter-transcription factor pairs, and metabolite sensors have allowed traditional dynamic circuits to obtain more robust functionality and improved dynamic properties.

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Citations

Oct 6, 2016·Biotechnology Letters·Irem Avcilar-Kucukgoze, Zoya Ignatova
Jan 5, 2017·Cold Spring Harbor Perspectives in Biology·Randall A Hughes, Andrew D Ellington
Jun 18, 2017·Physical Review. E·Joris PaijmansPieter Rein Ten Wolde
Jan 28, 2017·Nucleic Acids Research·Steven W SowaLydia M Contreras
Apr 9, 2018·Metabolic Engineering·Xia WangShihui Yang
Apr 14, 2021·Cell·Zibo Chen, Michael B Elowitz
Aug 11, 2017·ACS Synthetic Biology·Abigail N LeistraLydia M Contreras

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