Advances in systemic therapy for advanced pancreatobiliary malignancies

F1000Research
Thorvardur R HalfdanarsonMitesh J Borad

Abstract

Pancreatobiliary malignancies are relatively uncommon and the overall prognosis is poor. Treatment options for advanced disease are limited to systemic therapy for metastatic disease and a combination of systemic therapy and radiation therapy for locally advanced but unresectable tumors. There have been significant advances in the treatment of pancreatobiliary cancers in recent years but the prognosis for patient survival remains disappointingly poor. We review the current treatment options for locally advanced pancreatobiliary malignancies and highlight recent advances in systemic therapy, including novel approaches using targeted treatments.

References

Aug 1, 1996·Annals of Oncology : Official Journal of the European Society for Medical Oncology·B GlimeliusC Svensson
Jun 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H A BurrisD D Von Hoff
May 15, 2002·International Journal of Radiation Oncology, Biology, Physics·Hiroyuki ShinchiTakashi Aikou
Apr 16, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E Van CutsemD Von Hoff
Jun 2, 2004·Nature Reviews. Cancer·J Martin Brown, William R Wilson
Apr 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jennifer J KnoxMalcolm J Moore
Oct 3, 2006·International Journal of Radiation Oncology, Biology, Physics·Merav A Ben-DavidEdgar Ben-Josef
Dec 13, 2006·Critical Reviews in Oncology/hematology·Lara Maria PasettoSilvio Monfardini
Jan 18, 2007·World Journal of Gastroenterology : WJG·Stefan BoeckVolker Heinemann
Jan 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Florence HuguetChristophe Louvet
Apr 25, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Malcolm J MooreUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Jun 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Asma SultanaPaula Ghaneh
Jul 14, 2007·Cancer·Rachel P RiechelmannJennifer J Knox
May 2, 2008·The Oncologist·Aram F Hezel, Andrew X Zhu
May 13, 2008·International Journal of Radiation Oncology, Biology, Physics·Eric T ShinoharaJames M Metz
Aug 1, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G RandiC La Vecchia
Sep 23, 2008·International Journal of Radiation Oncology, Biology, Physics·John W NelsonBrian G Czito
Feb 10, 2009·International Journal of Radiation Oncology, Biology, Physics·Eric T ShinoharaJames M Metz
Feb 25, 2009·British Journal of Cancer·T AndréW Scheithauer
Mar 11, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christine A Iacobuzio-DonahueDaniel Laheru
Mar 20, 2009·International Journal of Radiation Oncology, Biology, Physics·Douglas G GoldDavid M Nagorney
Mar 25, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Florence HuguetDavid Azria
Jul 9, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Amanda BlackfordRalph H Hruban
Oct 28, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David CunninghamJohn P Neoptolemos
Feb 18, 2010·Surgical Oncology Clinics of North America·Ryan M Thomas, Syed A Ahmad
Apr 7, 2010·The Surgical Clinics of North America·E James Kruse
Apr 9, 2010·The New England Journal of Medicine·Juan ValleUNKNOWN ABC-02 Trial Investigators
Apr 30, 2010·The New England Journal of Medicine·Manuel Hidalgo
Jun 10, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sam J LubnerKyle D Holen
Jun 29, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F EckelUNKNOWN ESMO Guidelines Working Group
Jul 8, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hedy Lee KindlerRichard M Goldberg
Jul 8, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Philip A PhilipCharles D Blanke
Sep 9, 2010·JAMA : the Journal of the American Medical Association·John P NeoptolemosUNKNOWN European Study Group for Pancreatic Cancer
Sep 22, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Atul SharmaSurendra Pal Chaudhary

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Methods Mentioned

BETA
GTPase
exome sequencing

Software Mentioned

GEMOX

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