Advances in systemic therapy for metastatic breast cancer: future perspectives.

Medical Oncology
S P CoronaDaniele Generali

Abstract

Breast cancer (BC) is the most common cancer in women worldwide. One in eight women will develop the disease in her lifetime. Notwithstanding the incredible progress made in this field, BC still represents the second most common cause of cancer-related death in women. Targeted drugs have revolutionised breast cancer treatment and improved the prognosis as well as the life expectancy of millions of women. However, the phenomenon of primary and secondary pharmacological resistance is becoming increasingly evident, limiting the efficacy of these agents and calling for a better in-depth knowledge and understanding of the biology as well as the biochemical crosstalk underlying the disease. The advent of laboratory technologies in the clinical setting such as the routine use of next generation sequencing has allowed identification of new genetic alterations as well as providing a precise picture of the molecular landscapes of each tumour. Consequently, new specific therapeutic approaches are becoming available to minimise or delay the occurrence of resistance. In this review, we analyse the latest research and news from the clinical development side for each BC subtype.

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Citations

Oct 7, 2017·Future Oncology·Navid SobhaniDaniele Generali
Jan 10, 2019·World Journal of Clinical Oncology·Navid SobhaniBruna Scaggiante
Apr 15, 2019·Breast Cancer Research and Treatment·Daniel N CagneyAyal A Aizer
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Aug 14, 2021·The Breast : Official Journal of the European Society of Mastology·Oindrila BhattacharyyaSamilia Obeng-Gyasi
Dec 22, 2021·Expert Review of Vaccines·Maryam Abbaspour, Vajihe Akbari

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