Advances in the biology of bone metastasis: how the skeleton affects tumor behavior

Bone
Julie A SterlingGregory R Mundy

Abstract

It is increasingly evident that the microenvironment of bone can influence the cancer phenotype in many ways that favor growth in bone. The ability of cancer cells to adhere to bone matrix and to promote osteoclast formation are key requirements for the establishment and growth of bone metastases. Several cytokine products of breast cancers (e.g. PTHrP, IL-11, IL-8) have been shown to act upon host cells of the bone microenvironment to promote osteoclast formation, allowing for excessive bone resorption. The increased release of matrix-derived growth factors, especially TGF-β, acts back upon the tumor to facilitate further tumor expansion and enhance cytokine production, and also upon osteoblasts to suppress bone formation. This provides a self-perpetuating cycle of bone loss and tumor growth within the skeleton. Other contributing factors favoring tumor metastasis and colonization in bone include the unique structure and stiffness of skeletal tissue, along with the diverse cellular composition of the marrow environment (e.g. bone cells, stromal fibroblasts, immune cells), any of which can contribute to the phenotypic changes that can take place in metastatic deposits that favor their survival. Additionally, it is also apparent...Continue Reading

References

Jan 1, 1992·Journal of Cellular Biochemistry. Supplement·L W ChungJ S Rubin
Nov 1, 1992·Clinical Endocrinology·V GrillT J Martin
Jan 1, 1992·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·N J BundredJ G Ratcliffe
Jun 20, 1990·Journal of the National Cancer Institute·F ArguelloR B Baggs
Sep 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A A BudayrG J Strewler
Jun 1, 1980·The Quarterly Review of Biology·I R Hart, I J Fidler
Feb 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·J J WysolmerskiW M Philbrick
Apr 22, 1994·Science·P C BrooksD A Cheresh
Oct 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·E D Hay, A Zuk
Sep 6, 1994·Annals of the New York Academy of Sciences·S N MaitiE W Thompson
Jan 1, 1996·The Journal of Cell Biology·A Erlebacher, R Derynck
Jan 1, 1996·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·D R ClohisyM L Ramnaraine
Jan 1, 1995·Acta Anatomica·E D Hay
Jun 1, 1996·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·H LiapisS Kitazawa
Aug 22, 1996·International Journal of Cancer. Journal International Du Cancer·A BellahcèneV Castronovo
Mar 1, 1997·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·G R Mundy
May 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A BellahceneV Castronovo
May 1, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·O H Sanchez-SweatmanG Singh
Dec 9, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J D GrahamC L Clarke
Dec 17, 1997·International Journal of Cancer. Journal International Du Cancer·M T GillespieD M Findlay
Feb 14, 1998·The Journal of Cell Biology·L A CaryJ L Guan
Jun 20, 1998·The Journal of Cell Biology·M ScatenaC M Giachelli
Jul 11, 1998·Molecular Biology of the Cell·A ErlebacherR Derynck
Jul 17, 1998·Journal of the National Cancer Institute·D WaltregnyV Castronovo
Jul 29, 1998·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·F Hartveit
Jan 7, 1999·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·D R Clohisy, M L Ramnaraine
Feb 23, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Z BouizarM C De vernejoul
Jul 20, 1999·Clinical & Experimental Metastasis·M LelekakisR L Anderson
Jun 27, 2000·Biophysical Journal·C M LoY L Wang
Oct 18, 2000·Seminars in Radiation Oncology·B E Hillner

❮ Previous
Next ❯

Citations

Jul 17, 2012·Wiener medizinische Wochenschrift·Reinhard Gruber
Nov 18, 2011·Cancer Metastasis Reviews·Davina Cossigny, Gerald M Y Quan
Oct 20, 2012·Cancer Metastasis Reviews·Stefan StefanovicChristoph Domschke
Mar 16, 2013·Clinical & Experimental Metastasis·Jessica M GrundaGregory A Clines
Mar 23, 2011·Current Osteoporosis Reports·Julie A Sterling, Scott A Guelcher
Jul 27, 2011·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Scott A Guelcher, Julie A Sterling
Jan 5, 2011·Nature Reviews. Endocrinology·Larry J SuvaRobert J Griffin
Aug 11, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Qing Chen, Joan Massagué
Dec 29, 2013·Journal of Cancer Research and Clinical Oncology·Yinglong ZhangXiuchun Qiu
Jul 24, 2014·BioMed Research International·Denise BuenrostroJulie A Sterling
Dec 10, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Riadh BadraouiTarek Rebai
Sep 10, 2014·International Journal of Cell Biology·Moses O OyewumiFayez F Safadi
Nov 2, 2014·Clinical & Experimental Metastasis·Rachelle W JohnsonJulie A Sterling
Jan 31, 2016·Cancer Letters·Dixon H XuYujiang Fang
May 7, 2011·Expert Opinion on Emerging Drugs·Flaminia ColuzziConsalvo Mattia
Sep 28, 2013·Critical Reviews in Oncology/hematology·Thomas E KrugerJinxi Wang
May 3, 2011·Biomaterials·Marco A Lopez-HerediaX Frank Walboomers
Sep 21, 2010·Bone·Jochen G SchneiderKatherine N Weilbaecher
May 31, 2012·The Prostate·Bhavani KrishnanPatricia E Gallagher
Nov 21, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Farzin M TakyarNatalie A Sims
Jan 6, 2015·Reviews in Endocrine & Metabolic Disorders·T John Martin, Natalie A Sims
Nov 9, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·M GokulnathN Selvamurugan
Aug 26, 2015·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Dorota SkrajnowskaBlazej Gadzinski
Oct 21, 2016·Journal of Bone Oncology·Penelope D Ottewell
Jul 6, 2012·Expert Opinion on Therapeutic Targets·Maria GkotzamanidouEvangelos Terpos
Jun 27, 2015·Journal of Korean Neurosurgical Society·Sung Bae ParkChun Kee Chung

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Tumorigenesis

Breast tumorigenesis involves the production or formation of tumor(s) in breast tissue. Discover the latest research on breast tumorigenesis here.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Related Papers

Current Osteoporosis Reports
Julie A Sterling, Scott A Guelcher
The New England Journal of Medicine
G David Roodman
Breast Cancer Research : BCR
Yu-Chi ChenAndrea M Mastro
© 2021 Meta ULC. All rights reserved