Advances in the Development of Therapeutics for Cytomegalovirus Infections.

The Journal of Infectious Diseases
Edward AcostaRichard Whitley

Abstract

The development of therapeutics for cytomegalovirus (CMV) infections, while progressing, has not matched the pace of new treatments of human immunodeficiency virus (HIV) infections; nevertheless, recent developments in the treatment of CMV infections have resulted in improved human health and perhaps will encourage the development of new therapeutic approaches. First, the deployment of ganciclovir and valganciclovir for both the prevention and treatment of CMV infections and disease in transplant recipients has been further improved with the licensure of the efficacious and less toxic letermovir. Regardless, late-onset CMV disease, specifically pneumonia, remains problematic. Second, the treatment of congenital CMV infections with valganciclovir has beneficially improved both hearing and neurologic outcomes, both fundamental advances for these children. In these pediatric studies, viral load was decreased but not eliminated. Thus, an important lesson learned from studies in both populations is the need for new antiviral agents and the necessity for combination therapies as has been shown to be beneficial in the treatment of HIV infections, among others. The development of monoclonal antibodies, sirtuins, and cyclopropovir may p...Continue Reading

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Citations

May 28, 2020·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Margaret R JorgensonDidier A Mandelbrot
Aug 21, 2020·Antimicrobial Agents and Chemotherapy·Karoly TothTerry L Bowlin
Feb 12, 2021·Annals of Intensive Care·Laurent PapazianUNKNOWN Preemptive Herpesviridae Treatment Study Group, REVA Network
Mar 31, 2021·Infection·P PaglianoSilvano Esposito
Jun 3, 2021·Viruses·Marianne R PereraJohn H Sinclair
Jun 3, 2021·Current Opinion in Infectious Diseases·Oriol Manuel, Robin K Avery
Jun 11, 2021·The Journal of Infectious Diseases·Matthew D HallMindy I Davis

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