Advances in the diagnosis and treatment of hepatitis B

Current Opinion in Infectious Diseases
W Alazawi, G R Foster

Abstract

Hepatitis B virus is responsible for much morbidity and mortality worldwide. Although the armament of drugs licensed for its treatment grows, it is increasingly apparent that the efficacy of these drugs is dependent upon much more that their pharmacology. A better understanding of the natural history of chronic hepatitis B infection together with recent advances in the molecular biology of antiviral resistance have given added dimensions to physicians' decision-making thought processes. The present review outlines the recent advances in diagnostic testing that enable a better understanding of an individual patient's phase of illness and also how such information can update treatment choices better. In the second part of this review, the licensed therapies and their relative merits are discussed, as is their role in managing resistance to antiviral therapy.

References

Jul 9, 1998·The New England Journal of Medicine·C L LaiD F Gray
Jun 29, 1999·Advances in Virus Research·S GüntherH Will
Oct 21, 1999·The New England Journal of Medicine·J L DienstagN A Brown
Oct 26, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y BenhamouT Poynard
Mar 8, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A ErhardtD Häussinger
Mar 8, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H L ChanA S Lok
Oct 5, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S J Hadziyannis, D Vassilopoulos
May 31, 2002·Journal of Clinical Microbiology·Vincent A LopezLynn D Condreay
Sep 25, 2002·Microbes and Infection·Ruy M RibeiroAlan S Perelson
Oct 12, 2002·Journal of Medical Virology·Richard S TedderElizabeth H Boxall
Jan 4, 2003·Gastroenterology·Jules L DienstagEugene R Schiff
Jan 15, 2003·Journal of Medical Virology·Vladimir P ChulanovWolfram H Gerlich
Feb 28, 2003·The New England Journal of Medicine·Stephanos J HadziyannisUNKNOWN Adefovir Dipivoxil 438 Study Group
Feb 28, 2003·The New England Journal of Medicine·Patrick MarcellinUNKNOWN Adefovir Dipivoxil 437 Study Group
Aug 27, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chi-Jen ChuUNKNOWN U.S. HBV Epidemiology Study Group
Jan 16, 2004·Gastroenterology·Anna S F LokMary Castiglia
Mar 12, 2004·The New England Journal of Medicine·Don Ganem, Alfred M Prince
Sep 17, 2004·The New England Journal of Medicine·Patrick MarcellinUNKNOWN Peginterferon Alfa-2a HBeAg-Negative Chronic Hepatitis B Study Group
Oct 8, 2004·The New England Journal of Medicine·Yun-Fan LiawUNKNOWN Cirrhosis Asian Lamivudine Multicentre Study Group
Nov 27, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Florian van BömmelThomas Berg
Jan 11, 2005·Lancet·Harry L A JanssenUNKNOWN Rotterdam Foundation for Liver Research
Jul 1, 2005·The New England Journal of Medicine·George K K LauUNKNOWN Peginterferon Alfa-2a HBeAg-Positive Chronic Hepatitis B Study Group
Aug 9, 2005·Gastroenterology·Ching-Lung LaiUNKNOWN Telbivudine Phase II Investigator Group
Jan 5, 2006·JAMA : the Journal of the American Medical Association·Chien-Jen ChenUNKNOWN REVEAL-HBV Study Group
Feb 1, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Robert P Perrillo
Mar 10, 2006·The New England Journal of Medicine·Ting-Tsung ChangUNKNOWN BEHoLD AI463022 Study Group
Mar 10, 2006·The New England Journal of Medicine·Ching-Lung LaiUNKNOWN BEHoLD AI463027 Study Group
Mar 15, 2006·Gastroenterology·Uchenna H IloejeUNKNOWN Risk Evaluation of Viral Load Elevation and Associated Liver Disease/Cancer-In HBV (the REVEAL-HBV) Study Group
May 27, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yoon-Seon LeeSoo-Ok Kim
Jul 5, 2006·The American Journal of Gastroenterology·Gang ChenAlison A Evans
Jul 28, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Florian van BömmelThomas Berg
Oct 24, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marion G PetersUNKNOWN ACTG Protocol A5127 Team
Nov 8, 2006·Gastroenterology·Stephanos J HadziyannisUNKNOWN Adefovir Dipivoxil 438 Study Group
Mar 30, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jay H HoofnagleAnna S F Lok
Apr 20, 2007·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Fumitaka SuzukiHiromitsu Kumada
Apr 28, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Byung Chul YooHyo-Suk Lee
Jun 7, 2007·World Journal of Gastroenterology : WJG·W F LeemansR A de Man
Jun 29, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anna S LokUNKNOWN Hepatitis B Virus Drug Resistance Working Group
Jul 25, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Byung Chul YooHyo-Suk Lee
Jul 27, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jordan J FeldE Jenny Heathcote

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Citations

Jan 18, 2013·World Journal of Gastroenterology : WJG·Zhuo-Lun SongHong Zheng
Apr 10, 2012·Pharmacology & Therapeutics·Peter M GeorgeJane A Mitchell
Jan 6, 2012·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Yong-Zhong WangKe-Zhuan Zhu
Feb 24, 2012·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Ming ShiLu Xing
Aug 6, 2013·Journal of Immigrant and Minority Health·Tara VijayanMarion G Peters
May 9, 2013·European Journal of Gastroenterology & Hepatology·Umit B DoganMustafa S Akin

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