[Advances in the diagnostics of Alzheimer's disease].

Der Nervenarzt
U FiedlerJ Benninghoff

Abstract

Due to the demographic developments, diagnosis and treatment, dementia constitutes an increasing medical challenge and is likely to have an increasing socioeconomic impact. Dementia does not reflect a single disease but encompasses a variety of underlying conditions, heterogeneous clinical courses and therapeutic approaches, among which Alzheimer's disease represents the most common cause. Therefore, a thorough differential diagnosis of dementia is of major importance. To date the current diagnosis of dementia according to ICD-10/DMS-IV is based on clinical criteria. In addition, the concept of mild cognitive impairment comprises early cognitive dysfunction without clinically apparent dementia. Alzheimer's disease is more and more conceptualized as a disease continuum with mild cognitive impairment as an early and manifest dementia as the later stage of the disease. This review gives an overview on the current diagnostic approaches and the proposed revisions of diagnostic and research criteria for Alzheimer's disease.

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Nov 1, 1984·The American Journal of Psychiatry·W G RosenK L Davis
Oct 19, 2000·Fortschritte der Neurologie-Psychiatrie·R IhlC Kaupmannsennecke
Mar 3, 2004·Annals of Neurology·William E KlunkBengt Långström
Apr 9, 2005·Journal of the American Geriatrics Society·Ziad S NasreddineHoward Chertkow
May 13, 2009·Current Treatment Options in Cardiovascular Medicine·Larisa H Cavallari, Kathryn M Momary
Jan 28, 2010·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Francesco PanzaVincenzo Solfrizzi
Feb 9, 2010·Nature Reviews. Neurology·Giovanni B FrisoniPaul M Thompson
Feb 17, 2010·Nature Reviews. Neurology·Kaj BlennowHenrik Zetterberg
Oct 5, 2010·International Journal of Alzheimer's Disease·Philipp SpitzerJens Wiltfang
Jan 25, 2011·Brain : a Journal of Neurology·Charlotte Cordonnier, Wiesje M van der Flier
Apr 26, 2011·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Clifford R JackCreighton H Phelps
Jul 27, 2011·Der Nervenarzt·C KleinT Klockgether

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Citations

Nov 28, 2012·Zeitschrift für Gerontologie und Geriatrie·W Hofmann
Sep 14, 2014·Zeitschrift für Gerontologie und Geriatrie·I KilimannS Teipel
Oct 11, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Gabriele DoblhammerThomas Fritze
Aug 4, 2016·Molecular Medicine Reports·Huihui JiQinwen Wang
May 28, 2015·MMW Fortschritte der Medizin·W HewerMartin Haupt

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