Circular RNAs (circRNAs) are a class of endogenous non-coding RNAs (ncRNAs) with a closed-loop structure that are mainly produced by variable processing of precursor mRNAs (pre-mRNAs). They are widely present in all eukaryotes and are very stable. Currently, circRNA studies have become a hotspot in RNA research. It has been reported that circRNAs constitute a significant proportion of transcript expression, and some are significantly more abundantly expressed than other transcripts. CircRNAs have regulatory roles in gene expression and critical biological functions in the development of organisms, such as acting as microRNA sponges or as endogenous RNAs and biomarkers. As such, they may have useful functions in the diagnosis and treatment of diseases. CircRNAs have been found to play an important role in the development of several diseases, including atherosclerosis, neurological disorders, diabetes, and cancer. In this paper, we review the status of circRNA research, describe circRNA-related databases and the identification of circRNAs, discuss the role of circRNAs in human diseases such as colon cancer, atherosclerosis, and gastric cancer, and identify remaining research questions related to circRNAs.
Viroids are single-stranded covalently closed circular RNA molecules existing as highly base-paired rod-like structures
Two reactions of Haloferax volcanii RNA splicing enzymes: joining of exons and circularization of introns
Transcription factor and microRNA regulation in androgen-dependent and -independent prostate cancer cells
Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing
Expression of linear and novel circular forms of an INK4/ARF-associated non-coding RNA correlates with atherosclerosis risk
starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data
Circ2Traits: a comprehensive database for circular RNA potentially associated with disease and traits
LncRNA2Function: a comprehensive resource for functional investigation of human lncRNAs based on RNA-seq data
Improved and Promising Identification of Human MicroRNAs by Incorporating a High-Quality Negative Set
Comprehensive Circular RNA Profiling Reveals That hsa_circ_0005075, a New Circular RNA Biomarker, Is Involved in Hepatocellular Crcinoma Development
Improved prediction of protein-protein interactions using novel negative samples, features, and an ensemble classifier
ProLanGO: Protein Function Prediction Using Neural Machine Translation Based on a Recurrent Neural Network
DincRNA: a comprehensive web-based bioinformatics toolkit for exploring disease associations and ncRNA function
Developing a Multi-Dose Computational Model for Drug-Induced Hepatotoxicity Prediction Based on Toxicogenomics Data
Circular RNA circβ-catenin aggravates the malignant phenotype of non-small-cell lung cancer via encoding a peptide.
Microarray Identifies a Key Carcinogenic Circular RNA 0008594 That Is Related to Non-Small-Cell Lung Cancer Development and Lymph Node Metastasis and Promotes NSCLC Progression by Regulating the miR-760-Mediated PI3K/AKT and MEK/ERK Pathways.
Hsa_circ_0001879 promotes the progression of atherosclerosis by regulating the proliferation and migration of oxidation of low density lipoprotein (ox-LDL)-induced vascular endothelial cells via the miR-6873-5p-HDAC9 axis.
Biomarkers for Diabetes
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