Advances in the Isolation of Specific Monoclonal Rabbit Antibodies

Frontiers in Immunology
Zaibao ZhangHongyu Yuan

Abstract

The rabbit monoclonal antibodies (mAbs) have advantages in pharmaceuticals and diagnostics with high affinity and specificity. During the past decade, many techniques have been developed for isolating rabbit mAbs, including single B cell antibody technologies. This review describes the basic characterization of rabbit antibody repertoire and summarizes methods of hybridoma technologies, phage display platform, and single B cell antibody technologies. With advances in antibody function and repertoire analysis, rabbit mAbs will be widely used in therapeutic applications in the coming years.

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Citations

Nov 2, 2017·Oncotarget·Tsuyoshi HamadaShuji Ogino
Oct 1, 2020·Monoclonal Antibodies in Immunodiagnosis and Immunotherapy·Ruiyin ChuRachel Palmer
Dec 1, 2017·Antibodies·Juliet RashidianKelsea Cummings
Mar 23, 2018·Frontiers in Immunology·Weihsu C Chen, Christopher M Murawsky

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Methods Mentioned

BETA
phage display
fluorescence-activated cell sorting
FACS
genetic modification
enzyme-linked immunosorbent assay
chip

Software Mentioned

HybriFree

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