Advances in the Management of Pediatric Sarcomas.

Current Oncology Reports
Fiorela N Hernandez TejadaDouglas Harrison

Abstract

The prognosis of pediatric patients who present with metastatic or recurrent sarcomas remains poor. In this review, we summarize the advances in the management of metastatic and relapsed pediatric sarcoma by highlighting recent and future clinical trials. Research into the identification of novel therapies for refractory pediatric sarcomas continues to advance. Outcomes have not improved in several decades underlying a need for improved understanding of the biology behind these tumors and the identification of novel therapeutic molecular targets that can be exploited pharmacologically. Multiple challenges remain for novel therapy in sarcomas such as the selection of effective targets, management of toxicities, and the tumor microenvironment. Many unique challenges remain in the treatment of patients with refractory pediatric sarcomas. Multiple strategies and targets are under investigation that hold promise.

References

Feb 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stefan S BielackKurt Winkler
May 14, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Leo KagerUNKNOWN Cooperative German-Austrian-Swiss Osteosarcoma Study Group
Jan 22, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Beate Kempf-BielackKurt Winkler
Mar 19, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paul A MeyersHolcombe Grier
May 4, 2005·Journal of Pediatric Surgery·Dave R LalMichael P La Quaglia
Oct 26, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stefano FerrariUNKNOWN Italian and Scandinavian Sarcoma Groups
Aug 10, 2006·Cancer Chemotherapy and Pharmacology·Robert L FineGregory Halligan
May 8, 2007·Cancer Cell·Franck TirodeOlivier Delattre
May 2, 2008·Current Treatment Options in Oncology·Stefan S BielackMichael Paulussen
May 10, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Odile OberlinJames R Anderson
Feb 25, 2009·Current Treatment Options in Oncology·Noah FedermanWilliam D Tap
May 7, 2009·Pediatric Blood & Cancer·Tanzina ChowdhuryDerek Roebuck
Jul 7, 2009·Pediatric Hematology and Oncology·Michela CasanovaAndrea Ferrari
Apr 21, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Malcolm A SmithGregory H Reaman
Jun 16, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ruth LadensteinHeribert Jürgens
Jan 20, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Vivek SubbiahPete M Anderson
Feb 2, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paul F RobbinsSteven A Rosenberg
May 12, 2011·PloS One·Cornelia von LevetzowElizabeth R Lawlor
Feb 11, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Andrea FerrariGianni Bisogno
Jun 5, 2012·The New England Journal of Medicine·Suzanne L TopalianMario Sznol
Oct 24, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Richard B WomerAaron R Weiss
Mar 8, 2014·Oncoimmunology·Stéphane ChampiatJean Charles Soria
Mar 29, 2014·The Cancer Journal·Sunitha Kakarla, Stephen Gottschalk
Jun 5, 2014·Current Oncology Reports·Aaron WeissDamon Reed
Jun 26, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Savita SankarStephen L Lessnick
Feb 1, 2015·Pediatric Blood & Cancer·Laura S van DamFriederike A G Meyer-Wentrup
Oct 28, 2014·Acta Oncologica·Thierry Alcindor
Dec 30, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Paul F RobbinsSteven A Rosenberg
Mar 3, 2015·Current Opinion in Immunology·Thomas BlankensteinHans Schreiber
Mar 10, 2015·Journal of Immunotherapy·Danielle M LussierJoseph N Blattman
Mar 25, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nabil AhmedStephen Gottschalk
Aug 13, 2015·Rare Tumors·Steven AttiaRobert G Maki
Aug 26, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nathalie GasparOdile Oberlin
Sep 10, 2015·Critical Reviews in Oncogenesis·Elizabeth R Lawlor, Poul H Sorensen
Sep 10, 2015·Critical Reviews in Oncogenesis·Jack F ShernJaved Khan
Nov 5, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Melinda S MerchantCrystal L Mackall

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Seminars in Oncology
Current Opinion in Oncology
Current Opinion in Oncology
Current Opinion in Oncology
Current Opinion in Oncology
© 2021 Meta ULC. All rights reserved