Advances in the microscopy of osteoarthritis

Microscopy Research and Technique
D L GardnerK Oates

Abstract

This review describes recent contributions made by microscopy to the understanding of osteoarthritis, a clinical syndrome the pathological features of which are well defined by classical white light microscopy. The fluorescence and reflected light, conventional and scanning optical microscopy of excised osteoarthritic tissue preparations, from human and animal sources, has enabled the identification of cell proteins such as S100, of matrix components such as the proteoglycans and collagens, and of adhesion molecules including fibronectin, the integrins and tenascin. Comparable microscopic studies have been made of cell and tissue culture preparations of osteoarthritic cartilage and synovium. Scanning optical microscopy also allows the rapid measurement, in hydrated osteoarthritic tissues, of cell density, cell size, surface roughness and other parameters. The importance of water in sustaining the physical attributes of cartilage is accepted and new forms of electron microscopy can play important parts in the study of unfixed osteoarthritic cartilage. These methods include the low temperature scanning electron microscopy and electron probe x-ray microanalysis of hydrated bulk material and the high resolution transmission electro...Continue Reading

References

Nov 30, 1979·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·R M Aspden, D W Hukins
Oct 1, 1992·Arthritis and Rheumatism·L S WilkinsonJ C Edwards
Apr 1, 1992·British Journal of Rheumatology·D M SalterD L Gardner
Jul 1, 1992·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·J P PelletierC J Malemud
Aug 1, 1992·The Journal of Pathology·W S HwangG N Hughes
Aug 1, 1992·Annals of the Rheumatic Diseases·D M FriedmanD Danilowicz
Nov 1, 1992·Arthritis and Rheumatism·S YamamotoT Yamamuro
Nov 1, 1992·Journal of Clinical Pathology·G AmirP A Revell
Sep 1, 1992·The Journal of Bone and Joint Surgery. British Volume·S D McArthur, D L Gardner
Aug 1, 1991·Current Opinion in Rheumatology·A J Reginato
Jun 1, 1991·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S R ShiK L Kalra
Jan 1, 1991·Scandinavian Journal of Rheumatology·A ZschäbitzW Reichel
Jan 1, 1992·The Journal of Bone and Joint Surgery. British Volume·N MitchellN Shepard
Nov 1, 1991·Bone and Mineral·J A HoylandA J Freemont
Jan 1, 1991·Bone·B Bak, T T Andreassen
Jun 1, 1991·Yonsei Medical Journal·N H KimI H Yang
Jan 1, 1991·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Y MoriM Kubo
Oct 1, 1990·British Journal of Rheumatology·H I Piirainen
Jan 1, 1990·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·J DunhamJ Chayen
Jan 1, 1985·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·J DunhamI H Muir
Jan 1, 1989·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·K K IshizueH J Mankin
Jan 1, 1989·Virchows Archiv. A, Pathological Anatomy and Histopathology·T OhtaS Ishii
Jan 1, 1989·Virchows Archiv. A, Pathological Anatomy and Histopathology·R LagierJ C Gerster
Feb 1, 1989·Seminars in Arthritis and Rheumatism·J Martel-Pelletier, J P Pelletier

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Citations

May 13, 1999·Progress in Histochemistry and Cytochemistry·K Ostergaard, D M Salter
Jan 29, 2011·Joint, Bone, Spine : Revue Du Rhumatisme·Paul MacMullanGeraldine McCarthy
Jun 2, 2011·Arthritis and Rheumatism·Bernd RolauffsWilhelm K Aicher
Apr 1, 2008·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Daniel SmolinskiMing H Zheng
Feb 26, 2011·Micron : the International Research and Review Journal for Microscopy·Nigel J FullwoodSang Joon Lee
Jul 10, 2007·Osteoarthritis and Cartilage·C W JonesM H Zheng
Oct 21, 2015·International Journal of Rheumatic Diseases·Morgana Duarte da SilvaAdair Roberto Soares Santos
Oct 27, 2005·Archives of Orthopaedic and Trauma Surgery·Gunter SpahnWerner Linss
Apr 6, 2012·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Yuze WangXiaochun Wei
Jun 26, 1998·Journal of Clinical Laser Medicine & Surgery

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