Advances in the possible treatment of COVID-19: A review

European Journal of Pharmacology
Pankaj ChibberGurdarshan Singh

Abstract

The emergence of the global pandemic caused by novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has put a challenge to identify or derive the therapeutics for its prevention and treatment. Despite the unprecedented advances in the modern medicinal system, currently, there are no proven effective therapies. However, rapid research on SARS-CoV-2 epidemiology help unveiling some new targets for potential drug therapies. Many drugs have been screened, and even their clinical trials are going on at an exceptional pace. Amongst these RNA-dependent RNA polymerase inhibitors (favipiravir and remdesivir) and steroids especially dexamethasone showed promising effects. The biological agents like tocilizumab, interferons, and convalescent plasma prove to be beneficial in viral clearance. Moreover, many immunomodulatory and viral S protein targeting vaccines have their ongoing clinical trials. The establishment of various in vitro and in vivo models for preclinical studies can additionally help the current research. The volume and the pace of the clinical trials launched to evaluate the safety and efficacy of various agents against coronavirus disease 2019 (COVID-19) reflect the need for high-quality evidence for various t...Continue Reading

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Methods Mentioned

BETA
glycosylation
transgenic

Clinical Trials Mentioned

NCT04307693
NCT04320277
NCT04323527
NCT04306497
NCT04325893
NCT04323592
NCT04315948
NCT04308668
NCT04328467
NCT04329923

Software Mentioned

Google Scholar
CELLECTRA

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