PMID: 11930591Apr 5, 2002Paper

Advances in the treatment of hepatitis C: combination antiviral therapy with interferon alfa-2b and ribavirin

Journal of the American Academy of Nurse Practitioners
L BensonB Casarico

Abstract

To provide nurse practitioners with the information to manage patients with chronic hepatitis C (HCV) receiving a new combination drug therapy containing ribavirin and interferon alfa-2b. Reviews of clinical trial results including large multicenter trials, Centers for Disease Control and Prevention documents, data from the drug manufacturer. This new therapy offers the potential for HCV remission or complete cure of the HCV infection. Although virologic responses are markedly improved with combination therapy, the side effects associated with combination therapy warrant regular patient monitoring, management, and medical intervention when clinically indicated. Combination therapy does not significantly worsen the side effects associated with mono-therapy, which are predictable, manageable, and reversible. However, proper patient education, symptom management, vigilance for serious side effects, and monitoring of hematologic parameters are critical to patient outcome.

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Citations

Nov 9, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Ashok B JainJohn J Fung
Sep 16, 2006·Gastroenterology Nursing : the Official Journal of the Society of Gastroenterology Nurses and Associates·Kate Sheppard, Ann Hubbert
Jun 18, 2010·The Nurse Practitioner·Christine S Brennan
Oct 13, 2009·Gastroenterology Nursing : the Official Journal of the Society of Gastroenterology Nurses and Associates·Tracy M Christianson, Donna Moralejo
Oct 24, 2003·The Journal of the Association of Nurses in AIDS Care : JANAC·Richard S Ferri, Carl A Kirton
Dec 6, 2007·Alimentary Pharmacology & Therapeutics·R S Brown
Jan 22, 2010·The Cochrane Database of Systematic Reviews·Jesper BrokChristian Gluud

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